Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Patent
1984-12-19
1986-07-01
Hollrah, Glennon H.
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
C07D29512
Patent
active
045981531
ABSTRACT:
A derivative of phencyclidine (1) bearing an isothiocyanate moiety of the meta position of the aromatic ring (2; Metaphit) has been synthesized and identified as a rapid and specific site-directed acylating agent of the [.sup.3 H]-phencyclidine binding site in rat brain homogenates.
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CA 95:197196j, Itzhak et al.; Recepter Binding and Antinociceptive Prop. of PCP Opiate-Like Derivatives, 1981.
CA 94:174824e, Itzhak et al., New Analgesic Drugs from PCP, 1981.
CA 95:24749p, Johnson et al.; Synthesis of Amine Devatives of PCP 1981.
CA 96:97667r, Lin et al., PCP Conjugates to Antigenic Proteins and Enzymes, 1982.
CA 89:215409p, Krastinat et al., General-Substituted Cycloalkones, 1978.
Contreras Patricia
Jacobson Arthur E.
Lessor Ralph A.
Mattson Mariena V.
O'Donohue Thomas L.
Dinner D. L.
Hollrah Glennon H.
Roberts, Jr. John S.
The United States of America as represented by the Department of
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