Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2007-01-30
2007-01-30
Haddad, Maher M. (Department: 1644)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C435S326000, C530S387300, C530S388260, C530S389100
Reexamination Certificate
active
10979092
ABSTRACT:
The present invention relates to novel metalloproteinase-like proteins. In particular, isolated nucleic acid molecules are provided encoding the human TACE-like and matrilysin-like proteins. TACE-like and matrilysin-like polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of TACE-like and matrilysin-like activity. Also provided are diagnostic methods for detecting cancer and therapeutic methods for cancer and other disorders characterized by an over or under production of these metalloproteinases.
REFERENCES:
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Brewer Laurie A.
Gentz Reiner L.
Ni Jian
Rosen Craig A.
Ruben Steven M.
Haddad Maher M.
Human Genome Sciences Inc.
Human Genome Sciences Inc.
Rooney Nora M.
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