Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1998-01-20
2000-04-04
Nashed, Nashaat
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
435 693, 435219, 435226, 43525233, 435325, 4353201, 536 231, 536 232, 536 235, C12P 2106
Patent
active
060460318
ABSTRACT:
The present invention relates to novel metalloproteinase-like proteins. In particular, isolated nucleic acid molecules are provided encoding the human TACE-like and matrilysin-like proteins. TACE-like and matrilysin-like polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of TACE-like and matrilysin-like activity. Also provided are diagnostic methods for detecting cancer and therapeutic methods for cancer and other disorders characterized by an over or under production of these metalloproteinases.
REFERENCES:
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Brewer Laurie
Gentz Reiner
Ni Jian
Rosen Craig
Ruben Steve
Brookes A. Anders
Human Genome Sciences Inc.
Nashed Nashaat
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