Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Amino acid sequence disclosed in whole or in part; or...
Reexamination Certificate
2011-06-14
2011-11-29
Rawlings, Stephen (Department: 1643)
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Amino acid sequence disclosed in whole or in part; or...
C530S328000, C530S345000, C530S350000, C424S192100, C424S193100, C424S277100
Reexamination Certificate
active
08067009
ABSTRACT:
The invention discloses identification and therapeutic use of matrix metalloproteinase oligopeptides and peptidomimetics. The oligopeptides are used for making antibodies. The antibodies are used for diagnostic and treatment purposes of various diseases. In particular, the diseases may involve the mechanism of degradation of extracellular matrix by MMP's during cell proliferation cycle. Suppression of MMP activity seems to arrest tumor growth during cancer progression. MMP oligopeptides were used as vaccines to treat mice having murine melanoma B16FO induced tumor. There was a significant drop in tumor weight and size for the group of mice that were immunized with MMP oligopeptide.
REFERENCES:
patent: 5646027 (1997-07-01), Ye et al.
patent: 2003/0139345 (2003-07-01), Netke et al.
Niedzwiecki Aleksandra
Rath Matthias W
Roomi Waheed M
Geeta Kadambi Riddhi IP LLC
Rath Matthias W.
Rawlings Stephen
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