Metalloproteinase inhibitory agent

Details Metalloproteinase inhibitory agent Metalloproteinase inhibitory agent

2007-04-24

2009-10-06

Russel, Jeffrey E (Department: 1654)

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Food or edible as carrier for pharmaceutical

C424S442000, C426S043000, C426S580000, C435S071200, C514S013800, C514S014800, C530S326000, C530S327000, C530S343000

Reexamination Certificate

active

07597904

ABSTRACT:
The present invention relates to an active agent, in particular a metalloproteinase inhibitory agent of casein-derived peptides obtained by hydrolysis of casein by a food grade bacteria. The invention also relates to the manufacture of an active agent, in which a food grade bacteria of the genusLactobacillus helveticusis contacted with casein in order to perform a hydrolysis and obtain casein-derived peptides exhibiting metalloproteinases inhibitory property. The present invention also includes isolated and purified inhibitory peptides obtained by hydrolysis of casein by the bacteria.

REFERENCES:
patent: 5866357 (1999-02-01), Dambmann et al.
patent: 6500798 (2002-12-01), Stanton et al.
patent: 6908633 (2005-06-01), Hayasawa et al.
patent: 7258996 (2007-08-01), Juillerat et al.
patent: 2002/0147144 (2002-10-01), Sidelman
patent: 2003/0144179 (2003-07-01), Takahasi et al.
patent: 4341193 (1992-11-01), None
patent: WO 94/28126 (1994-12-01), None
patent: WO 99/65326 (1999-12-01), None
patent: WO 01/68672 (2001-09-01), None
patent: WO 01/84948 (2001-11-01), None
patent: WO 91/13554 (2007-04-01), None
Schieber, A. et al., “Characterization of Oligo and Polypeptides Isolated From Yoghurt,” European Food Research and Technology, vol. 210, No. 5, pp. 310-313 (2000) XP 001106138.
Kohmura, M. et al., “Inhibition of Angiotensin-Converting Enzyme Bu Synthetic Peptide Fragmetns of Various Beta Caseins,” Agricultural and Biological Chemistry, vol. 54, No. 4, pp. 1101-1102 (1990) XP 001106729.
Otani, H. et al., “Studies on the Antigenic Structure of Bovine Beta Casein VI. Antigenic Activities of Peptides Produced By Tryptic and V8-Proteolytic Digestions of Peptide 110-144,” Milchwissenschaft, vol. 43, No. 12, pp. 759-761 (1988) XO001106112.
Eigel et al., “Nomenclature of Proteins of Cow's Milk: Fifth Revision,” Journal of Dairy Science, vol. 67, No. 8, pp. 1599-1631 (1984).
Enomoto et al., Antibodies Raised Against Peptide Fragments of Bovine alpha s1-Casein Cross-React With the Intact protein Only When the Peptides Contain Both B and T Cell Determinants; Molecular Immunology, vol. 27, No. 6, pp. 581-586 (1990).
Hegazi, “Proteolytic activity of lactic acid bacteria in skim milk with special reference to the biodegradation of casein fractions,” Die Nahrung, vol. 31, pp. 19-26 (1987).
Meisel et al., “Bioactive peptides encrypted in milk proteins: proteolytic activation and thropho-functional properties,” Antoine van Leeuwenhoek, vol. 76, pp. 207-215 (1999).
Robert et al., “Generation of Bioactive Peptides Derived from Caseins Using a Lactobacillus helveticus Strain,” Proceedings of the Second International and the Seventeenth America Peptide Symposium, American Peptide Society, pp. 770-771 (2001).
Yamamoto et al., “Antihypertensive Effect of the Peptides Derived from Casein by an Extracellular Proteinase from Lactobacillus helveticus CP790,” Journal of Dairy Science, vol. 77, No. 4, pp. 917-922 (1994).

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