Metalloproteinase inhibitors

Details Metalloproteinase inhibitors Metalloproteinase inhibitors

1997-09-08

1998-11-24

Geist, Gary

Organic compounds -- part of the class 532-570 series

Organic compounds

Hydroxamic acids, chalcogen analogs or salts thereof

562621, 562448, C07C25906, C07C23722, C07C22900

Patent

active

058409742

ABSTRACT:
Compound of formula (I) ##STR1## wherein Ar represents an optionally substituted phenyl or heteroaryl group, m is 1 or 2, n is 0, 1, 2, 3 or 4, X represents --COOH or --CONHOH and R.sub.1, R.sub.3 and Y are as defined in the specification,are inhibitors of metalloproteinases involved in tissue degradation.

REFERENCES:
Abreo et al. poster entitled "Truncated Succinamide Hydroxamates with Nanomolar Potency against Various MMPs," 213th ACS Meeting in San Francisco, 13th-17th Apr. 1997.
Chapman, et al., "Inhibition of Matrix Metalloproteinases by N-Carboxyalkyl Peptides," J. Med. Chem., 36:4293-4301 (1993).

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