Metalloproteinase inhibitors

Details Metalloproteinase inhibitors Metalloproteinase inhibitors

Filed on

1997-09-08

Date issued

1998-11-24

Examiner

Geist, Gary

Patent Class

Organic compounds -- part of the class 532-570 series

SubClass

Organic compounds

SubSubClass

Hydroxamic acids, chalcogen analogs or salts thereof

Other Related Categories

562621, 562448, C07C25906, C07C23722, C07C22900

Type

Patent

Status

active

Patent number

058409742

Description

ABSTRACT:
Compound of formula (I) ##STR1## wherein Ar represents an optionally substituted phenyl or heteroaryl group, m is 1 or 2, n is 0, 1, 2, 3 or 4, X represents --COOH or --CONHOH and R.sub.1, R.sub.3 and Y are as defined in the specification,are inhibitors of metalloproteinases involved in tissue degradation.

REFERENCES:
Abreo et al. poster entitled "Truncated Succinamide Hydroxamates with Nanomolar Potency against Various MMPs," 213th ACS Meeting in San Francisco, 13th-17th Apr. 1997.
Chapman, et al., "Inhibition of Matrix Metalloproteinases by N-Carboxyalkyl Peptides," J. Med. Chem., 36:4293-4301 (1993).

Affiliated with

Also associated with

Rating

Metalloproteinase inhibitors does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Metalloproteinase inhibitors, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Metalloproteinase inhibitors will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1704495