Metalloproteinase inhibitors

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

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C07D21375

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active

058592539

ABSTRACT:
L-tert-leucine-2-pyridylamide or an acid addition salt thereof.

REFERENCES:
patent: 4599361 (1986-07-01), Dickens et al.
Broughton et al., "Studies Concerning the Antibiotic Actinonin. Part VIII. Structure-Activity Relationships in the Actinonin Series," J. Chem. Soc., 9:857-860 (1975).
Cawston, et al, "Mammalian Collagenases," Meth. In Enzymol., 80:711-722 (1981).
Cawston, et al., "A Rapid and Reproducible Assay for Collagenase Using
Cawston, et al., "Purification of Rabbit Bone Inhibitor of Collagenase," Biochem. J., 195:159-165 (1981).
Devlin, et al., "Studies Concerning the Antibiotic Actinonin. Part III. Synthesis of Structural Analogues of Actinonin by the Anhydride-Imide Method," J. Chem. Soc. Perkin Trans I., 830-841 (1975).
Sellers, "Separation in Latent Forms of Distinct Enzymes that when Activated Degrade Collagen, Gelatin and Proteoglycans," Biochem. J., 171:493-496 (1978).
Woessner, "Matrix Metalloproteinases and their Inhibitors in Connective Tissue Remodeling," FASEB J., 5:2145-2154 (1991).

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