Metalloproteinase inhibitors

Details Metalloproteinase inhibitors Metalloproteinase inhibitors

1998-10-16

1999-07-06

Gerstl, Robert

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D27746

Patent

active

059199407

ABSTRACT:
The present invention relates to therapeutically active hydroxamic acid and carboxylic acid derivatives, to processes for their preparation, to pharmaceutical compositions containing them, and to the use of such compounds in medicine. In particular, the compounds are inhibitors of metalloproteinases involved in tissue degradation, and in addition are inhibitors of the release of tumor necrosis factor from cells.

REFERENCES:
patent: 4599361 (1986-07-01), Dickens et al.
patent: 5684008 (1997-11-01), Hallinan
Broughton et al., "Studies Concerning the Antibiotic Actinonin. Part VIII. Structure-Activity Relationships in the Actinonin Series," J. Chem. Soc., 9:857-860 (1975).
Cawston, et al, "Mammalian Collagenases," Meth. In Enzymol., 80:711-722 (1981).
Cawston, et al., "A Rapid and Reproducible Assay for Collagenase Using
Cawston, et al., "Purification of Rabbit Bone Inhibitor of Collagenase," Biochem. J., 195:159-165 (1981).
Devlin, et al., "Studies Concerning the Antibiotic Actinonin. Part III. Synthesis of Structural Analogues of Actinonin by the Anhydride-Imide Method," J. Chem. Soc. Perkin Trans I., 830-841 (1975).
Sellers, "Separation in Latent Forms of Distinct Enzymes that when Activated Degrade Collagen, Gelatin and Proteoglycans," Biochem. J., 171:493-496 (1978).
Woessner, "Matrix Metalloproteinases and their Inhibitors in Connective Tissue Remodeling," FASEB J., 5:2145-2154 (1991).

Affiliated with

Also associated with

Rating

Metalloproteinase inhibitors does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Metalloproteinase inhibitors, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Metalloproteinase inhibitors will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-900170