Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving hydrolase
Reexamination Certificate
2003-09-16
2009-08-11
Nashed, Nashaat T (Department: 1652)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving hydrolase
C435S219000, C514S002600, C514S012200, C514S013800, C514S014800, C514S015800, C530S350000, C530S300000
Reexamination Certificate
active
07572599
ABSTRACT:
It has been determined that metalloprotease cleavage of a myostatin pro peptide results in activation of a latent inactive myostatin to an active form. Accordingly, methods of identifying agents that modulate metalloprotease mediated activation of myostatin are provided, as are agents identified using such methods. Also provided are methods of modulating muscle growth in an organism by increasing or decreasing metalloprotease mediated cleavage of a myostatin pro peptide.
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Greenspan Daniel S.
Lee Se-Jin
McPherron Alexandra C.
Pappano William N.
Tomkinson Kathy
Chowdhury Iqbal H
DLA Piper (LLP) US
Nashed Nashaat T
The Johns Hopkins University School of Medicine
Wisconsin Alumni Research Foundation
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