Metallopeptides having stabilized secondary structures

Details Metallopeptides having stabilized secondary structures Metallopeptides having stabilized secondary structures

1990-10-02

1993-04-06

Cashion, Jr., Merrell C.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

Insulin; related peptides

530326, 530300, 530325, A61K 3702, A61K 3726, C07K 500, C07K 700

Patent

active

052005046

ABSTRACT:
The invention contemplates a metallopeptide and a method for producing the metallopeptide. The metallopeptide comprises a polypeptide bonded to a metal cation at two coordinating amino acid residues that are aqueous solvent-accessible, said metallopeptide having a secondary structure stabilized by said bonded metal cation.

REFERENCES:
patent: 4849505 (1989-07-01), Stavrianopoulos
Kemp et al., Tetrahedron Lett., vol. 29, pp. 4931-4934, 1988.
Ghadiri et al., J. Am. Chem. Soc., vol. 112, pp. 9633-9635, 1990.
Ghadiri et al., J. Am. Chem. Soc. 112: 1630-1632 (1990).
Ghadiri, et al., J. Am. Chem. Soc. 112; 9633-9635 (1990).

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