Metallo-organic salt compounds and pharmaceutical uses thereof

Details Metallo-organic salt compounds and pharmaceutical uses thereof Metallo-organic salt compounds and pharmaceutical uses thereof

1988-12-02

1991-09-17

Friedman, Stanley J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514183, A61K 3133, A61K 31555

Patent

active

050495577

ABSTRACT:
The present invention provides a complex compound having the structure: ##STR1## wherein R.sub.1 and R.sub.1, are the same or different and each is an alkyl group, a phenyl group or a substituted derivative of a phenyl group;

REFERENCES:
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The Preparation and Some Properties of Copper(II) and Nickel(II) Schiff Base Complexes Having Various Peripheral Substitutent Groups, Nagara, et al., Inorganic Chimica Acta, (1981) 47:37-40.
Action of N-Bromosuccinimide on Methine Carbons of N,N'-Bis(Benzoylacetone Ethylenediaminiatonickel(II) and Copper(II), Nagara et al., Inorg. Nucl. Chem. Letters, (1981) 17:235-237.
In-Plane Ligand Effects on Oxygenation of Cobalt(II) Schiff Base Complexes--Kasuga et al., Inorganica Chimica Acta, (1984) 84:113-116.
3-Methylpentane-2,4-Dione, Johnson et al., Organic Synthesis Collective vol. V, 785-786.
Spin-Pairing Model of Dioxygen Binding and Its Application to Various Transition-Metal Systems as well as Hemoglobin Cooperativity, Drago et al., Acc. Chem. Res. (1980) 13: 335-360.
Thermodynamics of Oxygen Binding in Natural and Synthetic Dioxygen Complexes, Niederhoffer et al., Chem. Rev. (1984) 84: 137-203.
Assigning Oxidation States to Some Metal Dioxygen Complexes of Biological Interest, Summerville, et al., Journal of Chemical Education (1979) 56: 3.

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