Metallation of macrocycles with 2,4-dicarbonyl-metal complexes

Details Metallation of macrocycles with 2,4-dicarbonyl-metal complexes Metallation of macrocycles with 2,4-dicarbonyl-metal complexes

1997-07-30

1999-03-23

Shah, Mukund J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Unsubstituted hydrocarbyl chain between the ring and the -c-...

540145, 540465, 534 11, 534 15, C07D48722, C07D25700

Patent

active

058861734

ABSTRACT:
A method has been developed which utilizes a metal-2,4-dicarbonyl complex as an organic solvent soluble metal ion source in the metallation of polyazamacrocycles including porphyrins, expanded porphyrins and porphyrinoid compounds. Use of a metal ion source which is soluble in the metallation reaction medium produces significantly higher yields of a measurably purer product than is achieved using an insoluble or only sparingly soluble metal salt as in the prior art. Additionally, because the metallation can be performed in relatively concentrated mixtures, the reaction times are dramatically shorter and the amount of waste produced is less than when simple metal salts serve as the metal ion source. Further, use of the soluble metal-2,4-dicarbonyl complex simplifies the purification protocol required for the metallated expanded porphyrin.

REFERENCES:
patent: 4935498 (1990-06-01), Sessler et al.
patent: 5252720 (1993-10-01), Sessler et al.
patent: 5256399 (1993-10-01), Sessler et al.
patent: 5272142 (1993-12-01), Sessler et al.
patent: 5292414 (1994-03-01), Sessler et al.
patent: 5591422 (1997-01-01), Hemmi et al.
R.G. Lauffer Magn. Reson Q. (1990) 6: 2.
C.F. Meares et al. Br. J. Cancer Suppl. (1990) 10: 21.
G. Jori et al. J. Photochem. Photobiol. B (1990) 6: 93.
S.W. Young et al. Proc. Nat. Acad. Sci. U.S.A. (1996) 93: 6610.
S.W. Young et al. Invest. Radiol. (1996) 31: 280.
J.L. Sessler et al. Accounts of Chemical Research (1994) 27: 43.
S.W. Young et al. Invest. Radiol. (1996) ??L 353.
J.F. Desreux Lanthanide Probes in Life, Chemical and Earth Sciences. Theory and Practice, Bunzli, J.--C.G. Ed., Elsevier, New York (1989) pp. 43-64.

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