Metallated halogenated acetylene corticoid synthesis

Details Metallated halogenated acetylene corticoid synthesis Metallated halogenated acetylene corticoid synthesis

1981-05-18

1982-08-03

Roberts, Elbert L.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

26039745, 26039747, 2603974, C07J 700

Patent

active

043427022

ABSTRACT:
A process for the preparation of corticoids (IX) which comprises reacting a 17-keto steroid (I) with a metallated halogenated acetylene (II) followed by reaction with a sulfenylating agent (IV) and C.sub.17 side chain rearrangement.

REFERENCES:
patent: 4041055 (1977-08-01), Shephard et al.
patent: 4154730 (1979-05-01), Torelli et al.
patent: 4183924 (1980-01-01), Green et al.
J. Am. Chem. Soc. 86, 3840 (1964).
D. E. O'Connor & W. I. Lyness, "The Effect of Methylmercapto, Methylsulfinyl, and Methylsulfonyl Groups on the Equilibrium in Three-Carbon Prototropic Systems".

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