Metal substituted non-centrosimmetrical phthalocyanine...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Silicon containing doai

Reexamination Certificate

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C514S185000, C540S124000, C540S125000

Reexamination Certificate

active

07153841

ABSTRACT:
Phthalocyanine analogues having an active group able to link the phthalocyanine t carriers molecules and phthalocyanine to carriers molecules and phthalocyanine analogues as phthalocyanine-carrier conjugates showing enhanced photodynamic properties, red shifted absorption characteristic, all useful for photodynamic therapy, are described.Photosensitizers themselves or the photosensitizers-carriers conjugates are useful compounds either for treatment of various infectious diseases, the in vivo eradication of micro-organisms as well as diseases characterized by cellular hyperproliferation, in particular tumours psoriasis, actinic keratosis, atheromas, endoarterial hyperplasia and prostate hyperplasia.The above compounds can be also useful for blood and blood derivatives sterilization and in vivo/vitro diagnostics.

REFERENCES:
patent: 0906758 (1999-04-01), None
patent: 0906758 (1999-07-01), None
patent: 1164135 (2001-12-01), None
Sastre, A. et al., “Synthesis of Novel Unsymmetrical Monoaminated Phthalocyanines,” Tetrahedron Letters, vol. 36 (No. 46), p. 8501-8504, (Nov. 13, 1995).
Hu, M. et al., “Hydroxyphtalocyanines as Potential Agents for Cancer Therapy,” J. Med. Chem, p. 1789-1802, (1998).
Herter, R. et al., “Synthesis of NIR-Absorbing Monofunctionalized Phtalocyanines via Copolymer Coupling,” Proc. Spie-Int. Soc. Opt. Eng., vol. 2625, p. 384-385, (1996).
Savitskii, A. P. et al., “Avidin-Biotin System as an Agent for Targeted Delivery of Antitumor Agents,” Ross. Khim. Zh., vol. 42 ( No. 5), p. 77-83, (1998).
Leznoff, C. C. et al., “The Synthesis of a Soluble, Unsymmetrical Phthalocyanine of a Polymer Support,” Tetrahedron Letters, vol. 23 ( No. 30), p. 3023-3026, (1982).
Reimlinger, H., “Nomeklatur Organisch-Chemischer Verbindungen,” Walter de Gruyter, p. 80-82, (Sep. 19, 1998).

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