Metal radionuclide labeled proteins for diagnosis and therapy

Details Metal radionuclide labeled proteins for diagnosis and therapy Metal radionuclide labeled proteins for diagnosis and therapy

1989-10-18

1991-08-06

Maples, John S.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

530390, 530402, A61K 39395

Patent

active

050376306

ABSTRACT:
Protein conjugated chelated metal radionuclides are provided for use in vivo. Intermediates are provided for preparing the polypeptide compositions efficiently.

REFERENCES:
patent: 4897255 (1990-01-01), Fritzberg et al.
Liang et al., "Serum Stability and Non-Specific Building of TC-99M". (Proceeding of 33rd Soc. of Nucl. Med., 6/22-25/86, Wash., DC), No. 720.
Fritzberg et al., "Radiolabeling of Antibodies with TC-99M using N.sub.2 S.sub.2 Liganos" (Proceedings of 33rd Soc. of Nucl. Med., 6/22-25/86, Wash., DC), No. 330.
Kasina et al., "Application of Diamide Dimercaptioe N.sub.2 S.sub.2 "(Sixth Inter Symp. on Radio-Pharm Chem., 6/29-7/3/86, Boston, No. 118.
Fritzberg, A. R., "Advances in 99M-TC Labeling of Antibodies", Nucl. Med., 26:7-12, 1987.

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