Metal oxide-assisted laser desorption/ionization mass...

Details Metal oxide-assisted laser desorption/ionization mass... Metal oxide-assisted laser desorption/ionization mass...

2006-10-17

2006-10-17

Wells, Nikita (Department: 2881)

Radiant energy

Ionic separation or analysis

With sample supply means

C250S281000, C250S493100

Reexamination Certificate

active

07122792

ABSTRACT:
The invention provides a simple, rapid and cost-effective metal oxide-assisted laser desorption/ionization mass spectrometry (MOALDI MS) without the addition of light-absorbing organic-matrix, comprising the use of (a) an inorganic metal oxide with light absorbing capability as an assisting material to render desorption/ionization of samples in laser desorption/ionization mass spectrometry and (b) a citric acid buffer as the proton source for enhancing the ionization efficiency for analytes. Metal oxide assisting materials is not only restricted to the uses of films. Metal oxide nanoparticles are also suitable to be used as the assisting materials. Low matrix background, stable surface feature, homogeneous sample deposition, and wide detectable mass range are the merits of MOALDI MS.

REFERENCES:
Koichi Tanaka, Yutaka Ido, et al. “Detection of High Mass Molecules by Laser Desorption Time-of-Flight Mass Spectrometry,” (1987) Central Research Lab., Shimadzu Corp., Kyoto, Japan (pp. 185-188).
Jan Sunner, Edward Dratz, et al. “Graphite Surface-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry of Peptides and Proteins from Liquid Solutions,” (1995) Dept. of Chem. and Biochem., Montana State Univ., Bozeman Montana, USA (pp. 4335-4342).
Jing Wei, Jillian M. Burial, et al. “Desorption-Ionization Mass Spectrometry on Porous Silicon” (1999) Dept. of Chem., Purdue Univ., West Lafayette, IN, USA (pp. 243-246).

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