Metal organo phosphorous compounds for NMR analysis

Details Metal organo phosphorous compounds for NMR analysis Metal organo phosphorous compounds for NMR analysis

1984-08-13

1988-06-07

Warden, Robert J.

Drug, bio-affecting and body treating compositions

In vivo diagnosis or in vivo testing

Magnetic imaging agent

128653, 128654, 534 10, 534 14, 534 15, 534 16, 556 13, 556 18, 556 19, 556 42, 556 45, 556 51, 556 57, A61K 4900, A61B 600

Patent

active

047495600

ABSTRACT:
The present invention relates to a class of compositions and a method for NMR imaging using an NMR signal affecting amount of a paramagnetic, diamagnetic or ferromagnetic metal ion chelated with an organo phosphorous compound.
Gadolinium bis(bis-dihydroxyphosphonylmethylphosphinate) is an example of such a composition.

REFERENCES:
patent: 3477953 (1969-11-01), Carlson
patent: 3534125 (1970-10-01), Knollmueller
patent: 3983227 (1976-09-01), Tofe et al.
patent: 4116990 (1978-09-01), Budnick
patent: 4229427 (1980-10-01), Whitehouse
patent: 4497744 (1985-02-01), Fawzi
patent: 4647447 (1987-03-01), Gries et al.

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