Metal-mediated halohydrin formation

Details Metal-mediated halohydrin formation Metal-mediated halohydrin formation

1984-01-18

1985-12-24

Evans, J. E.

Organic compounds -- part of the class 532-570 series

Organic compounds

Oxygen containing

556445, 560231, 560266, 568649, 568674, 568676, 568807, 568811, 568834, 568845, 568850, C07C 2964, C07C 3120, C07C 3134, C07C 3340

Patent

active

045608113

ABSTRACT:
Novel methods for making chlorohydrins are provided using a Lewis acid catalyst with an olefin and peroxy compound or where an enantiomer is desired, a Lewis acid catalyst in combination with a chiral alcohol, particularly glycol, and a combination of a peroxy compound and alkenol. In certain situations, an epoxide may be employed.

REFERENCES:
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patent: 2307875 (1943-01-01), Buc et al.
patent: 3351635 (1967-11-01), Kollar
patent: 4313008 (1982-01-01), Jones
K. Tani et al., Tetrahedron Letters (1979) 32:3017-3020.
S. Yamada et al, J. Am. Chem. Soc. (1977) 99:1988-1990.
R. Michaelson et al., J. Am. Chem. Soc. (1977) 99:1990-1992.
Katsuki and Sharpless, J. Am. Chem. Soc. (1980) 102:5974-5976.
Sharpless et al., Pure and Appl. Chem. (1983) 55:589-604.

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