Metal-lipid molecules

Details Metal-lipid molecules Metal-lipid molecules

1998-03-16

2000-09-19

Park, Hankyel

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Blood proteins or globulins, e.g., proteoglycans, platelet...

436 13, 4241781, 4241791, C07K 1600, G01N 3100, A61K 39395

Patent

active

061214256

ABSTRACT:
Novel metal-lipid molecules have the formula M-Or-L. M represents a cluster or colloid of atoms of Au, Ag, Pt, Pd, or combinations thereof. Or is an organic group covalently attached to the metal atoms. L represents a lipid moiety. In a preferred embodiment, M represents a cluster of about 50-70 gold atoms having a diameter of about 1.4 nm in diameter and L represents dipalmitoyl phosphatidyl ethanolamine.

REFERENCES:
patent: 4124524 (1978-11-01), Danielmeyer et al.
patent: 4313734 (1982-02-01), Leuvering
patent: 5116759 (1992-05-01), Klainer et al.
"A Novel Giant Palladium Cluster" by Michail N. Vargaftik, Victor P. Zagorodnikov, Igor P. Stolyarov, Ilya I. Moiseev, Vladimir A. Likholobov, Dmitry I. Kochubey, Andrew L. Chuvilin, Vladimir I. Zaikovsky, Kirill I. Zamaraev, and Galina I. Timofeeva, J. Chem. Soc., Chem. Commun., 1985.
"Nanogold.TM.--Fab' Access Nuclear Protein", NanoNews Newsletter, Winter, 1992, Issue No. 1.
"Colloidal Gold for Multiple Staining" by J. Doerr Schott, pp. 155-157, in Colloidal Gold, Principles, Methods and Applications, Academic Press (1989).
FITC-Protein A-Gold Complex for Light and Electron Microscopic Immunocytochemistry, by Jurgen Roth, Moise Bendayan, Lelio Orci, J. of Histochemistry 28: 55-57 (1980).
"Wheat Germ Agglutinin-apoHRP Gold: A New Retrograde Tracer for Light--and Electron-Microscopic Single--and Double-Label Studies", by A.I. Basbaum and D. Menetrey, The Journal of Comparative Neurology 261: 306-318 (1987).
"Probing Microtubule-Dependent Intracellular Motility with Nanometre Particle Video Ultamicroscopy (Nanovid Ultramicroscopy)", by M. DeBrabander, G. Geuens, R. Nuydens, M. Moeremans and J. DeMey, Cytobios 43 273-283 (1985).
"A 1.4nm Gold Cluster Covalently Attached to Antibodies Improves Immunolabeling", by James F. Hainfeld and Frederic R. Furuya, The Journal of Histochemistry and Cytochemistry, vol. 40, No. 2, pp. 177-184, 1992.
"Synthesis of Thiol-derivatised Gold Nanoparticles in a Two-Phase Liquid-Liquid System", by M.Brust,M. Walker, D. Bethell, D. Schiffrin, R. Whyman, J. Chem. Soc., Chem. Comm., 1994, pp. 801-802.
"Labeling Update", Product Review, Nature, vol. 356, Mar. 12, 1992, p. 177.
"Products from Nanoprobes" Catalog 1993, pp 1-12.
"Immunology: Pick of the Week", Product Review, Nature, vol. 353, Oct. 17, 1991, p. 680.
"Large Clusters and Colloids. Metals in the Embryonic State", by Gunter Schmid, Chemical Reviews, 1992, pp. 1709-1726.
"Ligand-Stabilized Giant Palladium Clusters: Promising Candidates in Heterogeneous Catalysis" by Gunter Schmid, J. Am. Chem. Soc. 1993, 115, 2046-2048.
"EPR on the High-Nuclearity Palladium Cluster Pd.sub.561 Phen.sub.36 O.sub.200 ", J. de Aguiar, H.B. Brom, L.J deJongh & G. Schimd, Z. Phys. D--Atoms, Molecules & Clusters 12, 457-459 (1989).
"Fresnel Effect in High Resolution Tem Imaging of Small Particles", V. Radmilovic & M.A. O'Keefe, Proc. 53rd Annual Meeting, Micros. Soc. Amer.; p. 564-565, New York, 1995.
"Pt.sub.309 Phen.sub.36 O.sub.30.+-.10, a Four-Shell Platinum Cluster", G. Schimd, B. Morun, J. Malm, Anew. Chem. Int. Ed. Engl. 28 (1989) No. 6, pp. 778-780.

Affiliated with

Also associated with

Rating

Metal-lipid molecules does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Metal-lipid molecules, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Metal-lipid molecules will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1074400