Metal-ligating amino acid derivatives for MRI and for peptide sy

Details Metal-ligating amino acid derivatives for MRI and for peptide sy Metal-ligating amino acid derivatives for MRI and for peptide sy

1992-07-30

1997-06-10

Shippen, Michael L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

534 16, 556 50, 556 63, 556116, 556134, 556148, 560 24, 560 32, 560 33, 562433, 562450, 562465, C07C26100

Patent

active

056377592

ABSTRACT:
Novel organic compounds and metal ion-containing amino acid chelates are described which are useful in solid phase synthesis of polypeptides and as magnetic resonance imaging (MRI) enhancing agents. The present invention also relates to a convenient and straightforward method to synthesize a metal-ligating amino acid suitable as MRI enhancing agents or for introducing a strong metal binding site at any chosen position in a peptide. Some compounds are designed to be compatible with N-.alpha.-Fmoc peptide synthesis strategy, and can easily be prepared on large scale. Thus, flexible linkers of different lengths and containing various structures can be placed between the .alpha.-carbon backbone of peptides and metal binding moieties. These peptides will provide a variety of affinity cleaving reagents which can be directed against protein or nucleic acid targets. Therefore, these molecules can serve as an important tool to study protein folding, protein-protein and protein-nucleic acid interactions.

REFERENCES:
patent: 4647447 (1987-03-01), Gries

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