Metal-isonitrile adducts for preparing radionuclide complexes fo

Details Metal-isonitrile adducts for preparing radionuclide complexes fo Metal-isonitrile adducts for preparing radionuclide complexes fo

1984-11-28

1987-11-17

Terapane, John F.

Organic compounds -- part of the class 532-570 series

Organic compounds

Radioactive metal containing

534 10, 424 11, 556 1, 556 37, 556 64, 556 81, 556118, 558302, A61K 4300, A61K 4900, C07F 108, C07C12120

Patent

active

047075449

ABSTRACT:
A method for preparing a coordination complex of an isonitrile ligand and radionuclide such as Tc, Ru, Co, Pt, Fe, Os, Ir, W, Re, Cr, Mo, Mn, Ni, Rh, Pd, Nb and Ta is disclosed. The method comprises preparing a soluble metal adduct of said isonitrile ligand by admixing said ligand with a salt of a displaceable metal having a complete d-electron shell selected from the group consisting of Zn, Ga, Cd, In, Sn, Hg, Tl, Pb and Bi to form a soluble metal-isonitrile salt, and admixing said metal isonitrile salt with a salt comprising said radioactive metal in a suitable solvent to displace said displaceable metal with the radioactive metal thereby forming said coordination. The complex is useful as a diagnostic agent for labelling liposomes or vesicles, and selected living cells containing lipid membranes, such as blood clots, myocardial tissue, gall bladder tissue, etc.

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