Metal ion labeling of carrier molecules

Details Metal ion labeling of carrier molecules Metal ion labeling of carrier molecules

1986-03-05

1988-03-22

Schain, Howard E.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Blood proteins or globulins, e.g., proteoglycans, platelet...

204131, 2041801, 424 11, 424 85, 436512, 436547, 436548, 530345, 530388, 530400, C07K 308, A61K 3900, A61K 3942, A61K 4300

Patent

active

047329742

ABSTRACT:
A conjugate of a protein or polypeptide and a metal ion is prepared by reacting a metal ion transfer complex comprising a chelate of 4,5-dihydroxyl-m-benzenedisulfonic acid or a salt thereof with a protein or polypeptide that is covalently bound to an exogenous chelating group having a greater affinity than 4,5-dihydroxyl-m-benzenedisulfonic acid for the metal ion.

REFERENCES:
patent: 4331647 (1982-05-01), Goldenberg
patent: 4421735 (1983-12-01), Haber et al.
patent: 4472509 (1984-09-01), Ganson et al.
patent: 4474690 (1984-10-01), Nylen
patent: 4569794 (1986-02-01), Smith et al.
patent: 4592998 (1986-06-01), Avrameas et al.
J. Inorg. Chem., 30:3107-3109 (1968).
P. Letkeman et al., J. Coord. Chem., 10:47-53 (1980).
M. A. Bassinger et al., Res. Comm. in Chem. Path. and Pharm., 36:519-522 (1982).
M. A. Basinger et al., Res. Comm. in Chem. Path. and Pharm., 34:351-358 (1981).
Moerlein et al., J. Nucl. Med. Biol., vol. K, pp. 277-287 (1981).
Catecholate Complexes of .sup.99m Tc, "Technetium in Chemistry and Nuclear Medicine", eds. E. Deutsch et al., Cortina International (1983).
Complexometric Titrations, Methuen & Co., Ltd., London (1969).

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