Metal ion-labeled bis-aminoethanethiol-targeting ligand...

Drug – bio-affecting and body treating compositions – In vivo diagnosis or in vivo testing

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C424S001110, C424S001530, C424S001650, C424S001730

Reexamination Certificate

active

07615208

ABSTRACT:
The invention provides, in a general sense, a new labeling strategy employing99mTc chelated with ethylenedicysteine (EC). EC is conjugated with a variety of ligands and chelated to99mTc for use as an imaging agent for tissue-specific diseases. The drug conjugates of the invention may also be used as a prognostic tool or as a tool to deliver therapeutics to specific sites within a mammalian body. Kits for use in tissue-specific disease imaging are also provided.

REFERENCES:
patent: 4141654 (1979-02-01), Wardlaw et al.
patent: 4181654 (1980-01-01), Weitl et al.
patent: 4279992 (1981-07-01), Boguslaski et al.
patent: 4418068 (1983-11-01), Jones
patent: 4507466 (1985-03-01), Tomalia et al.
patent: 4558120 (1985-12-01), Tomalia et al.
patent: 4568737 (1986-02-01), Tomalia et al.
patent: 4587329 (1986-05-01), Tomalia et al.
patent: 4631337 (1986-12-01), Tomalia et al.
patent: 4694064 (1987-09-01), Tomalia et al.
patent: 4713975 (1987-12-01), Tomalia et al.
patent: 4730968 (1988-03-01), Diperstein et al.
patent: 4732863 (1988-03-01), Tomasi et al.
patent: 4737550 (1988-04-01), Tomalia
patent: 4789542 (1988-12-01), Goodman et al.
patent: 4824659 (1989-04-01), Hawthorne
patent: 4832940 (1989-05-01), Ege
patent: 4857599 (1989-08-01), Tomalia et al.
patent: 4861869 (1989-08-01), Nicolotti et al.
patent: 4871779 (1989-10-01), Killat et al.
patent: 4925650 (1990-05-01), Nosco et al.
patent: 4965392 (1990-10-01), Fritzberg et al.
patent: 4988496 (1991-01-01), Srinivasan et al.
patent: 5013556 (1991-05-01), Woodle et al.
patent: 5071965 (1991-12-01), Dunn et al.
patent: 5087616 (1992-02-01), Myers et al.
patent: 5108921 (1992-04-01), Low et al.
patent: 5164294 (1992-11-01), Skold et al.
patent: 5242679 (1993-09-01), Fritzberg et al.
patent: 5268163 (1993-12-01), Verbruggen
patent: 5279811 (1994-01-01), Bergstein et al.
patent: 5310536 (1994-05-01), Srinivasan
patent: 5356793 (1994-10-01), Koezuka et al.
patent: 5364613 (1994-11-01), Sieving et al.
patent: 5412072 (1995-05-01), Sakurai et al.
patent: 5416016 (1995-05-01), Low et al.
patent: 5474756 (1995-12-01), Tweedle et al.
patent: 5517993 (1996-05-01), Unger et al.
patent: 5534241 (1996-07-01), Torchilin et al.
patent: 5541287 (1996-07-01), Yau et al.
patent: 5601800 (1997-02-01), Katti et al.
patent: 5605671 (1997-02-01), Lyle et al.
patent: 5605672 (1997-02-01), Bogdanov et al.
patent: 5608060 (1997-03-01), Axworthy et al.
patent: 5609847 (1997-03-01), Belinka et al.
patent: 5620675 (1997-04-01), McBride et al.
patent: 5635382 (1997-06-01), Low et al.
patent: 5635603 (1997-06-01), Hansen et al.
patent: 5643883 (1997-07-01), Marchase et al.
patent: 5648063 (1997-07-01), Gries et al.
patent: 5670132 (1997-09-01), Griffiths et al.
patent: 5674470 (1997-10-01), Tweedle et al.
patent: 5688487 (1997-11-01), Linder et al.
patent: 5688488 (1997-11-01), Low et al.
patent: 5716596 (1998-02-01), Dean et al.
patent: 5730968 (1998-03-01), Butterfield et al.
patent: 5820847 (1998-10-01), Low et al.
patent: 5830431 (1998-11-01), Srinivasan et al.
patent: 5834266 (1998-11-01), Crabtree et al.
patent: 5846519 (1998-12-01), Tweedle et al.
patent: 5847121 (1998-12-01), Yau et al.
patent: 5877289 (1999-03-01), Thorpe et al.
patent: 5880281 (1999-03-01), Argese et al.
patent: 5891468 (1999-04-01), Martin et al.
patent: 5908777 (1999-06-01), Lee et al.
patent: 5951964 (1999-09-01), Dean et al.
patent: 5955053 (1999-09-01), Marzilli et al.
patent: 5955605 (1999-09-01), Axworthy et al.
patent: 5958374 (1999-09-01), Meares et al.
patent: 5977163 (1999-11-01), Li et al.
patent: 5986074 (1999-11-01), Marzilli et al.
patent: 6033884 (2000-03-01), Woo et al.
patent: 6054436 (2000-04-01), Crabtree et al.
patent: 6071490 (2000-06-01), Griffiths et al.
patent: 6071533 (2000-06-01), Papahadjopoulos et al.
patent: 6083741 (2000-07-01), Hart et al.
patent: 6113946 (2000-09-01), Szoka et al.
patent: 6143274 (2000-11-01), Tweedle et al.
patent: 6177551 (2001-01-01), Kasina
patent: 6187286 (2001-02-01), Elmaleh et al.
patent: 6197278 (2001-03-01), Blankenberg et al.
patent: 6232295 (2001-05-01), Kayyem et al.
patent: 6251866 (2001-06-01), Prakash et al.
patent: 6262107 (2001-07-01), Li et al.
patent: 6440389 (2002-08-01), Rabito
patent: 6521209 (2003-02-01), Meade et al.
patent: 6610269 (2003-08-01), Klaveness et al.
patent: 6613305 (2003-09-01), Collins et al.
patent: 6656450 (2003-12-01), Hubin et al.
patent: 6692724 (2004-02-01), Yang et al.
patent: 6713046 (2004-03-01), Meade
patent: 6737247 (2004-05-01), Bogdanov et al.
patent: 7067111 (2006-06-01), Yang et al.
patent: 7121926 (2006-10-01), Sabde
patent: 7223380 (2007-05-01), Yang et al.
patent: 7229604 (2007-06-01), Yang et al.
patent: 7261875 (2007-08-01), Li et al.
patent: 2001/0034363 (2001-10-01), Li et al.
patent: 2001/0041189 (2001-11-01), Xu
patent: 2003/0013772 (2003-01-01), Murphy et al.
patent: 2003/0152512 (2003-08-01), Rajopadhye et al.
patent: 2003/0206865 (2003-11-01), Platzek et al.
patent: 1156091 (2001-11-01), None
patent: 2002-516823 (2002-06-01), None
patent: 2002-522382 (2002-07-01), None
patent: 2002-241307 (2002-08-01), None
patent: WO 91/16076 (1991-10-01), None
patent: WO 99/56792 (1991-10-01), None
patent: WO 95/28966 (1995-11-01), None
patent: WO 97/33552 (1997-09-01), None
patent: WO 98/08859 (1998-03-01), None
patent: WO 99/39748 (1999-08-01), None
patent: WO 99/49901 (1999-10-01), None
patent: WO 99/61512 (1999-12-01), None
patent: WO 00/45857 (2000-08-01), None
patent: WO 00/53233 (2000-09-01), None
patent: WO 00/61788 (2000-10-01), None
patent: WO 01/49324 (2001-07-01), None
patent: WO 01/80906 (2001-11-01), None
patent: WO 01/88106 (2001-11-01), None
patent: WO 01/91807 (2001-12-01), None
patent: WO 01/97843 (2001-12-01), None
patent: WO 02/06209 (2002-01-01), None
patent: WO 02/11677 (2002-02-01), None
patent: WO 02/39995 (2002-05-01), None
patent: WO 02/43775 (2002-06-01), None
patent: WO 02/056692 (2002-07-01), None
patent: WO 03/009874 (2003-02-01), None
patent: WO 03/051403 (2003-06-01), None
patent: WO 2006/016784 (2006-05-01), None
Anderson et al, Nucl. Med. Biol., vol. 22, No. 2, pp. 165-173.
Sun et al, J. Med. Chem., 1996, vol. 39, pp. 458-470.
Yang et al., “Noninvasive Assessment of tumor hypoxia with 99-m-tc labeled metronidazole,”Pharm. Res., 16:743-750, 1999.
U.S. Appl. No. 10/627,763, filed Jul. 28, 2003, Lin.
U.S. Appl. No. 11/737,694, filed Apr. 19, 2007, Yang.
U.S. Appl. No. 60/828,347, filed Oct. 5, 2005, Yang.
Abrams et al., “Technetium-99m-human polyclonal IgG radiolabeled via the hydrazino nicotinamide derivative for imaging focal sites of infection in rats,”J. Nucl. Med., 31:2022- 2028, 1990.
Aime et al., “Ternary Gd(III)L-HAS adducts: evidence for the replacement of inner-sphere water molecules by coordinating groups of the protein, implications for the design of contrast agents for MRI,”J. of Biol. Inorg. Chem., 5:488-497, 2000.
Alauddin and Conti, “Synthesis and preliminary evaluationo f 9-(4-{18F]-Fluoro-3-Hydroxymethylbutyl)guanine ([18F]FHBG): a new potential imaging agent for viral infection and gene therapy,”Nucl. Med. Biol., 25:175-180, 1998.
Alauddin et al., “Evaluation of 9-[(3-18F]-fluoro-1-hydroxy-2-propoxy)methyl]guanine ([18F]-FHPG) in vitro and in vivo as probe for PET imaging of gene incorporation and expression in tumors,”Nucl. Med. Biol., 26:371-376, 1999.
Alauddin et al., “Receptor mediated uptake of a radiolabeled contrast agent sensitive to β-galactosidase activity,”Nuc. Med. Biol., 30:261-265, 2003.
Alauddin et al., “Synthesis of 9-[(3-18F]-fluoro-1-hydroxy-2-propoxy)methyl]guanine ([18F]-FHPG): a potential imaging agent of viral infection and gene therapy using PET,”Nuc. Med. Biol., 23:787-792, 1996.
Alper et al., “Assessment of renal functional changes following transurethral prostatectomy suing tc-99m ethylenedicysteine,”J. Nuclear Med., 37:289P, Abstract No. 1292, 1996.
Anderson and Welch, “Radiometal-labeled agents (non-technetium) for diagnostic imaging,”Chem. Rev., 99:2219-2234, 1999.
Anderson et al., &#x

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Metal ion-labeled bis-aminoethanethiol-targeting ligand... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Metal ion-labeled bis-aminoethanethiol-targeting ligand..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Metal ion-labeled bis-aminoethanethiol-targeting ligand... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-4129907

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.