Drug – bio-affecting and body treating compositions – Lymphokine – Interferon
Patent
1993-02-25
1995-08-15
Walsh, Stephen G.
Drug, bio-affecting and body treating compositions
Lymphokine
Interferon
424 851, 424 854, 424499, 514 6, 530351, 530420, A61K 3766, A61K 914, C07K 1526
Patent
active
054417341
ABSTRACT:
The present invention provides for crystalline zinc-interferon alfa-2 (IFN .alpha.-2) having a monoclinic morphology. The present invention further provides for crystalline cobalt-IFN .alpha.-2, crystalline calcium-IFN .alpha.-2, and crystalline IFN .alpha.-2 having a serum half-life of at least about 12 hours when injected into a primate. The present invention further provides for a method for producing a crystalline IFN .alpha.-2 comprising forming a soluble metal-IFN .alpha.-2 complex, and equilibrating the soluble metal-IFN .alpha.-2 complex in solution with an acetate salt of the metal under conditions that will cause the metal-IFN .alpha.-2 solution to become supersaturated and form crystalline metal-IFN .alpha.-2. The present invention also includes crystalline metal-alfa interferon having monoclinic, plate and needle morphologies.
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Hruza Alan
McNemar Charles
Nagabhushan Nagamani
Nagabhushan Tattanahalli L.
Reichert Paul
Dulak Norman
Lunn Paul G.
Nelson James
Schering Corporation
Walsh Stephen G.
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