Compositions – Preservative agents – Anti-oxidants or chemical change inhibitants
Patent
1975-03-17
1978-11-07
Sneed, Helen M. S.
Compositions
Preservative agents
Anti-oxidants or chemical change inhibitants
252431N, 2603131, 26032661, 2603322A, 26034611, 560142, 562568, 260429R, 260568, 260583R, 260465D, 260397, 260586R, 2603405R, 260607R, 260329ME, 260609R, 260632R, 260644, 260645, 260668R, 2606839, 260958, 260962, 562435, 546 3, 546 2, 546 11, 546 12, 562450, 26032614R, 26032614T, 562567, 542442, 548344, C07F 1500
Patent
active
041245334
ABSTRACT:
Process for the homogeneous catalytic hydrogenation of .beta.-substituted-.alpha.-acylamido-acrylic acids which yields, after hydrogenation, an optically active mixture. The process comprises the hydrogenation of .beta.-substituted-.alpha.-acylamido-acrylic acids in the presence of an optically active coordinated metal complex hydrogenation catalyst, in which the metal is selected from the group consisting of rhodium, iridium, ruthenium, osmium, palladium and platinum.
This process is a generalized process for any asymmetric hydrogenation of .beta.-substituted-.alpha.-acylamido-acrylic acids in which one .alpha.-amino acid enantiomorph is the desired end-product. It is especially useful for the preparation of .alpha.-amino acids found in nature which possess optical activity and which have a hydrogen attached to the asymmetric center.
This invention also relates to new optically active coordinated metal complex hydrogenation catalysts.
REFERENCES:
patent: 3133943 (1964-05-01), Chatt et al.
patent: 3480659 (1969-11-01), Dewhirst
patent: 3489786 (1970-01-01), Dewhirst
patent: 3511880 (1970-05-01), Booth
patent: 3652614 (1972-03-01), Dewhirst
patent: 3759838 (1973-09-01), Dewhirst
patent: 3849480 (1974-11-01), Knowles et al.
patent: 4008281 (1977-02-01), Knowles et al.
Ziegler et al., Inorg. Chem. VII, No. 4, pp. 695 to 702 (1972).
Chemical Abstracts, V58, 9867b (1963).
Chemical Abstracts, V70, 50980k (1969).
Chemical Abstracts, V66, 101196m (1967).
Chemical Abstracts, V70, 47551r (1969).
Chemical Abstracts, V67, 104724p (1967).
Chemical Abstracts, V70, 19517r (1969).
Knowles William S.
Sabacky Milton J.
Grattan Edward P.
Monsanto Company
Sneed Helen M. S.
Stanley Howard C.
Wexler Robert E.
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