Organic compounds -- part of the class 532-570 series – Organic compounds – Radioactive metal containing
Patent
1994-04-08
1997-02-11
Kight, John
Organic compounds -- part of the class 532-570 series
Organic compounds
Radioactive metal containing
534 14, 534 15, 534 16, 544 4, 544 47, 544 49, 544225, 544237, 546141, 546142, 546146, 546147, 546150, 546 4, 540 3, C07F 500, C07F 1300, C07J 7300
Patent
active
056022360
ABSTRACT:
Metal-containing steroid mimic complexes are provided. Compositions containing a metal ion incorporated into a steroid skeleton structure and ligands useful in the preparation of such compositions are also provided. The metal ion is preferably a radionuclide, such as technetium, rhenium or gallium. Methods for using the metal complexes for diagnostic and therapeutic purposes are further provided.
REFERENCES:
patent: 3492293 (1970-01-01), Fried
patent: 4030886 (1977-06-01), Bayly et al.
patent: 4083947 (1978-04-01), Monks et al.
patent: 4171351 (1979-10-01), Van der Veek
patent: 4202876 (1980-05-01), Monks et al.
patent: 4879379 (1989-11-01), Kidani
patent: 4983646 (1991-01-01), Jaouen et al.
patent: 5330737 (1994-07-01), Rajagopalan
Chi, et al., J. Med. Chem, vol. 37, No. 7 (1994) "Homodimeric and Heterodimeric Bis(amino thiol) Oxometal Complexes with Rhenium (V) and Technetium (V). Control of Heterodimeric Complex Formation and an Approach to Metal Complexes that Mimic Steroid Hormones", pp. 928-937.
Top, et al., J. Chem Soc., Chem., (1993) "Synthetic Strategy for Organometallic Complexes of Rhenium with Exceptionally High Affinity for the Oestradiol Receptor"; their Potential Use as Imaging and Therapeutic Agents, pp. 453-454.
Chi et al., J., Am. Chem. Soc., vol. 115, No. 15, (1993) "Selective Formation of Heterodimeric Bis-Bidentate Aminothiol-Oxometal Complexes of Rhenium (V)", pp. 7045-7046, see Scheme 1.
Donegan, Cancer Supplement, vol. 70, No. 6 (1992) "Prognostic Factors: Stage and Receptor Status in Breast Cancer", pp. 1755-1764.
Rayter, Br. J. Surg., vol. 78, No. 5 (1991) "Steroid receptors in breast cancer".
Wilding, Cancer Surveys, vol. 14: Growth Regulation by Nuclear Hormone Receptors (1992) "The Importance of Steroid Hormones in Prostate Cancer", pp. 113-130.
King, J. Steroid Biiochem. Molec. Biol., vol. 39, No. 5B (1991) "A Discussion of the Roles of Oestrogen and Progestin in Human Mammary Carcinogenesis", pp. 811-818.
Labrie, Endocrinology and Metabolism Clinics of North America, vol. 20, No. 4 (1991), "Endocrine Therapy for Prostate Cancer", pp. 845-872.
DE 4,104,257 as abstracted in CA 118:6878, 1992.
DE 3,827,727 as abstracted in CA 113:132024, 1990.
Chapman Lara E.
Kight John
Mallinckrodt Medical Inc.
McBride Thomas P.
LandOfFree
Metal-containing steroid mimics and ligands useful in the prepar does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Metal-containing steroid mimics and ligands useful in the prepar, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Metal-containing steroid mimics and ligands useful in the prepar will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-343121