Metal complexes that contain perfluoroalkyl, process for...

Drug – bio-affecting and body treating compositions – In vivo diagnosis or in vivo testing – Magnetic imaging agent

Reexamination Certificate

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C424S009361, C424S009363, C424S009365, C424S001650, C424S009400

Reexamination Certificate

active

06916461

ABSTRACT:
The invention relates to new, monomeric, perfluoroalkyl-substituted metal complexes, processes for their production, and their use in diagnosis and therapy.The compounds according to the invention are suitable especially as in vivo contrast media in nuclear spin tomography (MRT). They can preferably be used as blood-pool agents and as lymphographic agents.

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Gong et al.,Magn. Reson Imaging, vol. 9, No. 1 (1991) pp. 101-106: “Paramater Optimization and Callbration of Fluorine-19 Magnetic Resonance Imaging at 1.5 Tesia”.
Lee et al.,J. Magn. Reson Imaging, vol. 4, No. 4 (1994), pp. 609-613: “In Vivo Fluorine-19 MR Imaging: Relaxation Enhancement with Gd-DTPA”.
Ratner et al.,Invest Radiol., vol. 24, No. 3 (1989), pp. 224-227: “Fluorine-19 Relaxation Rate Enhancement and Frequency Shift with Gadolinium-DTPA”.
Thomas et al.,J. Magn. Reson Imaging, vol. 4, No. 4 (1994), pp. 631-635: “Evaluation of the influence of the Aqueous Phase Bioconstituent Environment on the F-19 T1 of Perfluorocarbon Blood Substitute Emulstions”.
International Search Report, Norwegian, Nov. 14, 2001.

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