Organic compounds -- part of the class 532-570 series – Organic compounds – Rare earth containing
Patent
1996-09-13
1998-09-01
Raymond, Richard L.
Organic compounds -- part of the class 532-570 series
Organic compounds
Rare earth containing
534 11, 534 13, 534 16, 540145, 540465, 540472, C07D48722
Patent
active
058012290
ABSTRACT:
Texaphyrins are provided for use as radiation sensitizers. Advantageous properties of texaphyrins for use as a radiation sensitizer include: i) a low redox potential which allows radiation-induced hydrated electrons to flow to texaphyrin rather than neutralizing hydroxyl radicals, allowing hydroxyl radicals to cause cellular damage, ii) a relatively stable texaphyrin radical that reacts readily to covalently modify neighboring molecules causing further cellular damage, iii) intrinsic biolocalization, and iv) indifference to the presence or absence of O.sub.2. These properties allow texaphyrins to be particularly effective for treating the hypoxic areas of solid neoplasms. Methods of treatment for an individual having a neoplasm or atheroma include the use of a texaphyrin as a radiation sensitizer and as an agent for photodynamic tumor therapy, or the use of a texaphyrin for internal and for external ionizing radiation. Novel texaphyrins are provided.
REFERENCES:
patent: 5457183 (1995-10-01), Sessler et al.
Hemmi Gregory W.
Kral Vladimir A.
Mody Tarak D.
Sessler Jonathan L.
Larson, Esq. Jacqueline S.
Raymond Richard L.
The Board of Regents University of Texas System
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