Metal complexes of N-methyl-11-aza-10-deoxo-10-dihydro-erythromy

Details Metal complexes of N-methyl-11-aza-10-deoxo-10-dihydro-erythromy Metal complexes of N-methyl-11-aza-10-deoxo-10-dihydro-erythromy

1987-09-09

1990-10-16

Brown, Johnnie R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

536 72, 536 74, A61K 3171, C07H 1708

Patent

active

049635280

ABSTRACT:
New 2:1 complexes of N-methyl-11-aza-10-deoxo-10-dihydroerythromycin A or 11-aza-10-deoxo-10-dihydroerythromycin A with bivalent metals chosen form the group comprising Cu.sup.+2, Zn.sup.+2, Co.sup.+2, Ni.sup.+2 and Ca.sup.+2, a process for their manufacture and their use in the manufacture of antibiotically active pharmaceuticals.
New 2:1 complexes of N-methyl-11-aza-10-deoxo-10-dihydroerythromycin A or 11-aza-10-deoxo-10-dihydroerythromycin A with bivalent metals chosen from the group comprising Cu.sup.+2, Zn.sup.+2, Co.sup.+2, Ni.sup.+2 and Ca.sup.+2 are made by reacting N-methyl-11-aza-10-deoxo-10-dihydroerythromycin A or 11-aza-10-deoxo-10-dihydroerythromycin A in its free base form or in its water-soluble salt form with salts of said bivalent metals. The compounds possess antibiotic activity.

REFERENCES:
patent: 4328334 (1982-05-01), Kobrehel et al.
patent: 4474768 (1984-10-01), Bright
patent: 4499083 (1985-02-01), Umezawa et al.
Burrows, Textbook of Microbiology (1973), Publ. by W. B. Saunders Company, p. 279.
Niebergall et al., J. Pharm. Pharmac., 1966, 18, 729-738.

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