Metal complexes of N-acetyl-glucosaminyl-N-acetyl-muramoyl-L-ala

Details Metal complexes of N-acetyl-glucosaminyl-N-acetyl-muramoyl-L-ala Metal complexes of N-acetyl-glucosaminyl-N-acetyl-muramoyl-L-ala

1989-12-04

1991-11-12

Doll, John

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514322, A61K 3702

Patent

active

050648128

ABSTRACT:
A complex of N-acetyl-glucosaminyl-N-acetyl-muramoyl-L-alanyl-D-isoglotaminyl- (L)-meso-diamino-pimelyl-(D-amide)-D-alanyl-D-alanine with bivalent metals chosen from the group comprising Cu.sup.2+, Zn.sup.2+, Co.sub.hu 2+ ; Ni.sup.2+ and Cd.sup.2+ in the molar ratio of the organic ligand: Cu.sup.2+ =2:1 and the organic ligand: Zn.sup.2+ or Co.sup.2+ or Ni.sup.2+ or Cd.sup.2+ =1:1, compositions containing it and their use in the treatment of immunological insufficiencies and disturbances in humans and animals.

REFERENCES:
patent: 4545932 (1985-10-01), Takase et al.
Hoyle et al., Metal Binding by the Peptidoglycan Sacculus of E. coli K--12, Can J. Microbiol, vol. 30, 1984, 204.
Klaic, B. .sup.13 C--N.m.r. Studies of a natural immunoadjuvant, pephdoglycan monomer and related compounds.
Sigel et al. Coordinating Prop of the Amide Bond. Stability & Strut of metal Ion Complexes of Peptides & Rel. Ligands, Chem Rev. 1982.

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