Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1985-10-01
1987-08-04
Rizzo, Nicholas S.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
514283, 540465, 540478, A61K 31475, C07D51904
Patent
active
046846387
ABSTRACT:
The invention relates to new aqueous pharmaceutical compositions containing as active ingredient a pharmaceutically acceptable complex of a bis-indole compound with a bi- or multivalent metal ion in a therapeutically effective amount. The invention further relates to complexes formed between a bis-indole compound and a bi- or multivalent metal ion.
According to another aspect of the invention there is provided a process for the preparation of a pharmaceutically acceptable metal complex of a bis-indole compound and optionally stable aqueous pharmaceutical compositions containing said metal complex, in which a solution of a bis-indole compound or a pharmaceutically acceptable salt thereof in an aqueous medium is reacted with a non-toxic water soluble salt of a bi- or multivalent metal capable of complexation, at a pH of 3.0 to 6.0, optionally in the presence of or followed by the addition of a conventional pharmaceutical carrier and/or further additive, or, if desired, the obtained complex is isolated.
The aqueous pharmaceutical compositions according to the invention have substantially increased stability.
REFERENCES:
patent: 2008252 (1935-07-01), Jostes et al.
patent: 3426024 (1969-02-01), Harvey
patent: 4073901 (1978-02-01), Buchel et al.
patent: 4309415 (1982-01-01), Horrobin
Campean, et al., Chemical Abstracts, vol. 95, 35487c (1981), and Chemical Abstracts Chemical Subject Index, vol. 95, p. 7315CS.
Burger Kalman
Gazdag Maria
Nagy Geza T.
Papp nee Sziklay Zsofia
Szepesi Gabor
Dubno Herbert
Myers Jonathan
Richter Gedeon Vegyeszeti Gyar Rt.
Rivers Diana G.
Rizzo Nicholas S.
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