Metal complexes for promoting catalytic cleavage of RNA by trans

Details Metal complexes for promoting catalytic cleavage of RNA by trans Metal complexes for promoting catalytic cleavage of RNA by trans

1995-02-17

1997-11-04

Rories, Charles C. P.

Organic compounds -- part of the class 532-570 series

Organic compounds

Unsubstituted hydrocarbyl chain between the ring and the -c-...

540465, 556 1, 556 6, 536 245, 536 231, 435 6, 435325, 435375, 435377, 514 44, 514 79, C07D25700, C07F 500, C12N 510, C07H 2100

Patent

active

056841493

ABSTRACT:
The present invention provides the first examples of metal complexes that show catalytic behavior in RNA transesterification under physiological relevant conditions i.e., 37.degree. C. and neutral pH. The metal complexes are catalytically active and kinetically inert to metal ion dissociation.
The metal complexes are formed by the union of a central metal ion with a non-metallic ion or molecule. The metal ion comprises copper, zinc, cobalt, nickel, palladium, lead, iridium, maganese, iron, molybdenum, vanadium, titanium, ruthenium, bismuth, cadmium, yttrium, magnesium, rhodium, uranium, the transition metals and the Lanthanide metals. The non-metallic ion comprises a ligand or complexing agent. The preferred ligand is one which strongly chelates lanthanides, and more preferably, forms a cationic complex of the lanthanides.

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