Metal complexes as cysteine protease inhibitors

Details Metal complexes as cysteine protease inhibitors Metal complexes as cysteine protease inhibitors

1996-09-27

1999-03-09

Nazario-Gonzalez, Porfirio

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heavy metal containing doai

514495, 514499, 514501, 536 171, 536 221, 536 231, 556113, 556114, 556116, 556117, A61K 3128, C07H 2300, C07F 108

Patent

active

058801499

ABSTRACT:
The invention relates to metal complexes used to bind proteins and enzymes.

REFERENCES:
Chakraborty, H. et al., "Catalytic Activities of Schiff Base Aquocomplexes of Copper(ii) in the Hydrolysis of Amino Esters," Chemical Abstracts, 122(7):1154, abstract: 81932t (1995).
Vol'pin, M.E. et al., "Transition Metal Complexes as Catalysts in Biochemical Systems. Interaction with Electron Transfer Processes," Chemical Abstracts, 95:212, abstract: 182415f (1981).
Wu, Z. et al., "Synthesis of Chelates of 2-HOC.sub.4 H.sub.4 (CHNCH.sub.2 CH.sub.2 OH) with Cobalt(II), Nickel(II), Copper(II) and Primary Tests of Their Anticancer Activities," Chemical Abstracts, 107(6):749, abstract: 50768e (1987).
Hu, V.W. et al., "X-Ray Absorption Edge Studies on Oxidized and Reduced Cytochrome c Oxidase," Chemical Abstracts, 87(23):235-236, abstract: 179854c (1987).
DeFilippo, D. et al., "Silver and Gold(I) Complexes with Thiomorpholin-3-One. Kinetics of Reduction of Gold(III)," 75(6):315, abstract:40913e (1971).
Sun Bai, K and D.L. Leussing, "Kinetics of Formation of N-Salicylideneglycinatonickel(II), -Copper(II) and -Zinc(II). Elucidation of the Template Mechanism," Journal of the American Chemical Society, 89(24):6126-6130 (1967).
Roeper, J., et al., "Square-Planar Copper(II) Chelate Complexes of the ONN,X Type (X-Monodentate Ligand): Kinetics of Ligand Substitution as Studied in Acetone and the Effect of Water," Chemcical Abstracts, 111(2):660, abstract: 16690w (1989).
Becker, M. et al., "Kinetics of Ligand Substitution in Platinum(II) Complexes: A Study on the Concept of Nucleophillic Discrimination," Chemical Abstracts, 105(22):750, abstract: 202128v (1966).
Elo, H. et al., "Antiproliferative Activity of Derivatives of Trans-bis(Salicyladoximato Copper (II) in Vitro. Some In Vivo Properties of the Parent Compound," Chemical Abstracts, 108(13):24, abstract: 106022x (1968).
Elo, H. et al., "Reaction of the Antiproliferative and Antineoplastic Agent Trans-Bis(Salicylaldoximato) Copper(II) and Related Chelates with Glutathione and Cysteine. Corelation Between Reactivity and Biological Activity," 107(18):918, abstract: 167735h (1987).
Meade et al., U.S. Ser. No. 08/571,364, filed Dec. 12, 1995, entitled "Cobalt Schiff Base Compounds".
Meade et al., U.S. Ser. No. 08/570,761, filed Dec. 12, 1995, entitled "Cobalt Schiff Base Compounds".
Meade et al., U.S. Ser. No. 08/358,068, filed Dec. 14, 1994, entitled "Water Soluble CO(II) Schiff's Base Compounds".
Doraswamy et al., Indian Journal of Chemistry, vol. 15A, No. 2, pp. 129-131, Feb. 1977.
Jani et al., Indian Journal of Chemistry, vol. 15A, No. 8, pp. 750-752, Aug. 1977.
Patel et al., Indian Journal of Chemistry, vol. 20A, No. 6, pp. 628-629, Jun. 1981.
Roper et al., Inorganic Chemistry, vol. 28, No. 12, pp. 2323-2329, Jun. 1989.
Costes et al., Inorganica Chimica Acta, vol. 237, Nos. 1-2, pp. 57-63, Sep. 1995.

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