Metal complex-protein composite and hydrogenation catalyst

Details Metal complex-protein composite and hydrogenation catalyst Metal complex-protein composite and hydrogenation catalyst

2006-06-13

2006-06-13

Weber, Jon (Department: 1653)

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Blood proteins or globulins, e.g., proteoglycans, platelet...

C530S400000, C530S223000, C530S389600, C514S002600, C514S006900

Reexamination Certificate

active

07060803

ABSTRACT:
A metal complex-protein composite comprising apohemoglobin, apoheme oxygenase, apocatalase or apoferrin having cavity and a metal complex has a specific structure that the metal complex is received in the cavity of the apoprotein. The metal complex is prepared by complexation of a metal ion, which is selected from the group consisting of rhodium, ruthenium, and palladium, with a ligand. The metal complex-protein composite functions as a hydrogenation catalyst of an olefin in water. The metal complex-protein composite is thus effectively applied to hydrogenation of water-soluble subtrates and has enviromental advantages over organic solvents.

REFERENCES:
Yu et al. (1999) Disordered water within a hydrophobic protein cavity visualized by x-ray crystallography. Proc. Natl. Acad. Sci. U S A. vol. 96, No. 1, pp. 103-108.
NCBI Sequence Viewer (2005) CAA48412, muoglobin amino acid sequence, http://www.nci.nlm.nih.gov/entrez/viewer.fcgi?db=protein&val=10120.
NCBI Sequence Viewer (2005) NP 776306, muoglobin amino acid sequence, http://www.nci.nlm.nih.gov/entrez/viewer.fcgi?db=protein&val=27806939.
Zhu et al. (1994) Site-specific hydrolytic. cleavage of cytochrome c and of its heme undecapeptide, promoted by coordination complexes of palladium(II), J. Am. Chan. Soc. vol. 116, pp. 5218-5224.
Cadierno et al. (May 2003) Ruthenium(II) and ruthenium(IV) complexes containing kappa1-P-, kappa2-P,O-, and kappa3-P,N,O-iminophosphorane-phosphine ligands Ph2PCH2P[=NP(=O)(OR)2]Ph2 (R = Et, Ph): synthesis, reactivity, theoretical studies, and catalytic activity in transfer hydrogenation of cyclohexanone. Inorg. Chem. vol. 42, No. 10, pp. 3293-3307.
Smolenski et al. (Mar. 2003) New rhodium(III) and ruthenium(II) water-soluble complexes with 3,5-diaza-1-methyl-1-azonia-7-phosphatricyclo[3.3.1.1(3,7)]decane. Inorg. Chem. vol. 42, No. 10, pp. 3318-3322.
Witting et al. (2001) Reaction of human myoglobin and H2O2. Electron transfer between tyrosine 103 phenoxyl radical and cysteine 110 yields a protein-thiyl radical. J. Biol. Chem. vol. 276, No. 19, pp. 16540-16547.
Wagner et al. (1995) Structure determination of the biliverdin apomyoglobin complex: crystal structure analysis of two crystal forms at 1.4 and 1.5 Angstroms resolution. J. Mol. Biol. vol. 247, No. 2, pp. 326-337.
Jackson et al. (2000) placement of Ru(bpy)2 in the heme pocket of cytochrome B5, Book of Abstract, 219th ACS National Meeting, San Francisco, CA, Mar. 26-30, 2000, Abstract No. 510.
Ohde et al. (2002) Hydrogenation of olefins in supercritical CO(2) catalyzed by palladium nanoparticles in a water-in-CO(2) microemulsion. J. Am. Chem. Soc. vol. 124, No. 17, pp. 4540-4541.
M. Ohashi et al. “Abstracts of Symposium on Biofunctional Chemistry,” Chiba University, Sep. 20-21, 2001. (w/ translation).
J. M. Brown et al. “The Mechanism of Asymmetric Homogeneous Hydrogenation. Solvent Complexes and Dihydrides from Rhodium Diphosphine Precursors,” Journal of Organometallic Chemistry, vol. 216, 1981, pp. 263-276.
T. Matsui et al. “Formation and Catalytic Roles of Compound I in the Hydrogen Peroxide-Dependent Oxidations by HIS64 Myoglobin Mutants,” J. Am. Chem. Soc., vol. 121, 1999, pp. 9952-9957.
F. Ascoli et al. “Preparation and Properties of Apohemoglobin and Reconstituted Hemoglobins,” Methods in Enzymology, vol. 76, 1981, pp. 72-87.
R. Baughn et al. “Conversion of a Protein to a Homogeneous Asymmetric Hydrogenation Catalyst by Site-Specific Modification with a Diphosphinerhodium(I) Moiety,” Journal of the American Chemical Society, 100:1, Jan. 4, 1978, pp. 306-307.
J. Collot et al. “Artificial Metalloenzymes for Enantioselective Catalysis Based on Biotin-Avidin,” J. Am. Chem. Soc., vol. 125, 2003, pp. 9030-9031.

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