Metal-chelating surfacant

Details Metal-chelating surfacant Metal-chelating surfacant

1998-06-02

2000-07-11

Davenport, Avis M.

Synthetic resins or natural rubbers -- part of the class 520 ser

Synthetic resins

Mixing of two or more solid polymers; mixing of solid...

525299, 525 90, 523 1, 523407, 524 68, 436 56, 436 73, 530402, C08F29300, C08L 304, C08L 5300, C07K 100, C07K 1400

Patent

active

06087452&

ABSTRACT:
A modified surfactant of the PLURONIC.TM.-type compound and method for manufacture is disclosed. The surfactant compound has at least one PEO block attached at a first end to at least one PPO block, with at least one of the PEO block having an organic metal-chelating end group (R) attached to a second end, the remaining PEO blocks having an unmodified hydroxyl group at the second end. The metal-chelating group is charged with an metal-ion. A protein with a metal-affinity tag, e.g., a histidine tag, is then complexed with the metal-chelating group to form a complex of the modified surfactant, the metal ion, and the protein. The modified surfactant may be adsorbed upon a hydrophobic surface, charged with a metal ion, and then complexed with a protein with a metal-affinity tag. A surface with specific activity toward proteins is the presented, which is suitable for applications where a protein is immobilized upon a surface to give the surface specific protein activity.

REFERENCES:
patent: 5516703 (1996-05-01), Caldwell
patent: 5674677 (1997-10-01), Peterson

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