Metal chelating compounds having an SNNN donor set

Details Metal chelating compounds having an SNNN donor set Metal chelating compounds having an SNNN donor set

1997-08-26

1999-12-21

Clardy, S. Mark

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

In an organic compound

424 169, 534 10, 534 14, 534 16, 5483275, 558254, A61K 5104, C07F 500, C07D23328, C07C32700

Patent

active

060045310

ABSTRACT:
Ligands for radiopharmaceutical use are capable of chelating radiometal species and of being bound to biological targeting molecules. The ligands have formula (a) and (b), where A, A'=--SZ or Y, B.dbd.O or S, Y.dbd. (c), Z.dbd.H or a thiol protecting group, m=2 or 3, n=2 or 3, q=0 or 1, R.dbd.H or unsubstituted or substituted hydrocarbon and pharmaceutically acceptable salts, provided that at least one CR.sub.2 group represents CO and forms, together with an adjacent N atom, a --CONR-- amide group. ##STR1##

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