Organic compounds -- part of the class 532-570 series – Organic compounds – Rare earth containing
Patent
1994-05-31
1995-10-31
Geist, Gary L.
Organic compounds -- part of the class 532-570 series
Organic compounds
Rare earth containing
424 9365, C07F 500, A61K 4900, A61K 5104
Patent
active
054630304
ABSTRACT:
The present invention relates to a new group of compounds (e.g., N,N"-bis(2,6-dimethylcarbaniloylmethylene diethylene triamino triacetic acid, N,N"-bis(pyridoxylamine)diethylene triamino triacetic acid) which can be used as metal chelating agents and can be complexed with paramagnetic metal atoms form new complexes with improved and unexpected stability which make them extremely useful as contrast agents in magnetic resonance imaging and other types of diagnostic imaging. The chelating agents and corresponding paramagnetic metal complexes are derivatives of diethylene triamino pentaacetic acid and triethylene tetraamino hexaacetic acid.
REFERENCES:
patent: 3859337 (1975-01-01), Herz et al.
patent: 4647447 (1987-03-01), Gries et al.
patent: 4687658 (1987-08-01), Quay
patent: 4687659 (1987-08-01), Quay
patent: 4746507 (1988-05-01), Quag
patent: 4826673 (1989-05-01), Dean et al.
patent: 4859451 (1989-08-01), Quay et al.
patent: 4885363 (1989-12-01), Tweedle et al.
patent: 4935518 (1990-06-01), Rocklage et al.
patent: 4957939 (1990-09-01), Gries et al.
patent: 4963344 (1990-10-01), Gries et al.
patent: 5011925 (1991-04-01), Rajagopalan et al.
patent: 5077037 (1991-12-01), Wallace
patent: 5130120 (1992-07-01), Weber
patent: 5138040 (1992-11-01), Moore et al.
Derwent abstract AN 91-052707 of EP 413405, 1991.
Krishnamurthy et al., "Technetium-99m-Iminodiacetic Acid Organic Anions: Review of Biokinetics and Clinical Application in Hepatology", Hepatology, vol. 9, pp. 139-153, 1989.
Bydder et al., "Clinical Use of Contrast Media in Magnetic Resonance Imaging", British Journal of Hospital Medicine, vol. 43, pp. 149-152, 1990.
Vittadini et al., "B-19036, A Potential New Hepatobiliary Contrast for MP Proton Imaging", Investigative Radiology 1988; 23 (Supp 1) S246-S248.
Shtern et al., "MR. Imaging of Blood-borne Liver Matastases in Mice: Contrast Enhancement with Fe-EHPG", Radiology 1991; 178:83-89.
Engelstad et al., "Hepatobiliary Magnetic Resonance Contrast Agents Assessed by Gadolinium-153 Scintigraply", Radiology 1987; 22:232-238.
Elizondo et al., "Preclinical Evaluation of MnDPDP: New Paramagnetic Hepatobiliary Contrast Agent for MR Imaging", Radiology 1991; 178:83-78.
Pavone et al., "Comparison of Gd-BOPTA with GD-DTPA in MR Imaging of Rat Liver" Radiology 1990; 176:61-64.
Saeed et al., "Occlusive and Reperfused Myocardial Infarcts: Differentiation with MnDPDP - enhanced MR Imaging", Radiology 1989; 172:59-64.
Schneider Richard F.
Subramanian Gopal
Chapman Lara E.
Geist Gary L.
Research Foundation of the State of New York
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