Metal chelate protein conjugate

Details Metal chelate protein conjugate Metal chelate protein conjugate

1985-04-26

1989-04-25

Lee, Mary C.

Organic compounds -- part of the class 532-570 series

Organic compounds

Isothiocyanate esters

548547, 562553, C07C16104, C07C 7940, C07D20740

Patent

active

048249866

ABSTRACT:
A method of forming a novel metal chelate protein conjugate is described. Also described are metal chelates and precursor compounds to the metal chelates. The novel metal chelate protein conjugates are particularly useful in the diagnostic imaging of tumors and in tumor therapy.

REFERENCES:
patent: 4454106 (1984-06-01), Gansow et al.
patent: 4472509 (1984-09-01), Gansow et al.
Chemical Abstracts, vol. 83, No. 8, 1975, Sundberg et al., "Chelating Agents for the Binding of Metal Ions to Macromolecules", 587-8.
Biological Abstract, vol. 80, No. 3, 1985, Lauffer et al., "Preparation and Water Relaxation Properties of Proteins Labeled with Paramagnetic Metal Chelates", 11-16.
International PCT Search Report.
Yeh et al, "A New Route to `Bifunctional` Chelating Agents: Conversion of Amino Acids to Analogs of Ethylenedinitrilotetraacetic Acid," Analytical Biochemistry, 100, 152-159 (1979).
Meares et al, "Metal Chelates as Probes of Biological Systems," Acc. Chem. Res., 17, 202-209 (1984).

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