Metal chelate forming peptides and use thereof

Details Metal chelate forming peptides and use thereof Metal chelate forming peptides and use thereof

1995-12-20

1998-06-23

Kight, John

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

In an organic compound

424 111, 424 165, 534 14, 530300, 530331, A61K 5100, A61M 3614

Patent

active

057701784

ABSTRACT:
The invention provides a metal chelate forming peptide having an amino acid sequence of three amino acid residues represented by: X1-X2-Cys, wherein X1 represents an amino acid residue other than Cys residue; X2 represents an amino acid residue other than Cys residue and Pro residue; functional groups at the N-terminus, C-terminus and side chain may be substituted with protecting groups; and each of the amino acid residues may be any of D-form and L-form. Further, the invention provides a complex of the peptide with a physiologically active peptide, protein or other substance; a labeled reagent obtained by labeling the peptide or the complex with a metal radionuclide; and a radiodiagnostic and radiotherapeutic composition comprising the metal radionuclide-labeled reagent.

REFERENCES:
patent: 5277892 (1994-01-01), Rhodes
patent: 5443816 (1995-08-01), Zamora et al.
patent: 5464934 (1995-11-01), Dunn et al.
patent: 5508020 (1996-04-01), Dean et al.
patent: 5552525 (1996-09-01), Dean
patent: 5556609 (1996-09-01), Zamora
patent: 5561220 (1996-10-01), Dean et al.
patent: 5591593 (1997-01-01), Courtenay-Luck
Pearson et al, J. Med. Chem. 39(7):1361-1371 (1996).
6th World Congress of Nuclear Medicine and Biology, Oct. 23-28, 1994, S46.
Knight et al. Thrombus Imaging with Technetium-99m Syntheic Peptides Based upon the Binding-Domain of a Monoclonal Antibody to Activated Platelets, Feb. 1994, vol. 35 No. 2.

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