Chemistry: analytical and immunological testing – Involving production or treatment of antibody – Monoclonal antibody
Patent
1982-06-07
1984-09-18
Hunt, Brooks H.
Chemistry: analytical and immunological testing
Involving production or treatment of antibody
Monoclonal antibody
436804, 436819, 436813, 436811, 260429J, 424 11, 424 9, 424 85, 424 86, A61K 3900, A61K 3942, A61K 4300, A61K 4900
Patent
active
044725094
ABSTRACT:
Methods of manufacturing and purifying metal chelate conjugated monoclonal antibodies are described. The chelated metal may be one which emits alpha, beta or gamma radiation, or positrons. Alternatively, the metal can be one which is fluorogenic or paramagnetic. The conjugates are suited for diagnostic and therapeutic uses.
REFERENCES:
patent: 3961038 (1976-06-01), Benes
patent: 4196265 (1980-04-01), Koprowski et al.
patent: 4311688 (1982-01-01), Burchiel et al.
patent: 4323546 (1982-04-01), Crockford et al.
patent: 4331647 (1982-05-01), Goldenberg
patent: 4339426 (1982-07-01), Meares et al.
patent: 4348376 (1982-09-01), Goldenberg
patent: 4349689 (1982-09-01), Aristoff
patent: 4352751 (1982-10-01), Wieder et al.
patent: 4361544 (1982-11-01), Goldenberg
patent: 4364920 (1982-12-01), Winchell
patent: 4385046 (1983-05-01), Milbrath et al.
patent: 4401824 (1983-08-01), Aristoff
Scheinberg et al., Science, vol. 215, pp. 1511-1513, (3-82).
Krejcarek, G. E. et al., Biochemical Biophysical Research Communications, vol. 77(2), pp. 581-585, 1977.
Khaw et al., Science, vol. 209, pp. 295-297, (1980).
Meares et al., Proc. Natl. Acad. Sci. U.S.A., 73: 3803-3806, (1976).
Hnatowich et al., Int'l. J. App. Radiat. Isot., 33: 326-332, (1982).
Paik et al., J. Nuc. Med., 22: 32, (1981).
Paik et al., J. Radioanal. Chem., 57: 553-564, (1980).
Bloomer et al., Science, 212: 340-341, (1981).
Zucchini et al., Int. J. Nucl. Med. & Biol., 9: 83-84, (1982).
Scheinberg et al., "Leukemic Cell Targeting and Therapy by Monoclonal Antibody in a Mouse Model System," (1982), Cancer Research 42:44-49.
Scheinberg et al., "Targeting in Erythroleukemic Mice: Radioiodinated and Chelated Radiometal-Conjugated Monoclonal Antibody," in Monoclonal Antibodies in Drug Development, pp. 159-171, (J. T. August ed. 1982).
Gansow Otto A.
Strand Mette
Hunt Brooks H.
Moskowitz M.
LandOfFree
Metal chelate conjugated monoclonal antibodies does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Metal chelate conjugated monoclonal antibodies, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Metal chelate conjugated monoclonal antibodies will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-794534