Metal-binding therapeutic peptides

Chemistry: molecular biology and microbiology – Vector – per se

Reexamination Certificate

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C536S023400, C530S324000, C435S069700

Reexamination Certificate

active

07618816

ABSTRACT:
The present invention is related methods of delivering MBD peptide-linked agents into live cells. The methods described herein comprise contacting MBD peptide-linked agents to live cells under a condition of cellular stress. The methods of the invention may be used for therapeutic or diagnostic purposes.

REFERENCES:
patent: 4683202 (1987-07-01), Mullis
patent: 5824467 (1998-10-01), Mascarenhas
patent: 5861273 (1999-01-01), Olson et al.
patent: 5914254 (1999-06-01), Mascarenhas et al.
patent: 6087090 (2000-07-01), Mascarenhas
patent: 6251639 (2001-06-01), Kurn
patent: 6630160 (2003-10-01), Evans et al.
patent: 6692918 (2004-02-01), Kurn
patent: 6914049 (2005-07-01), Mascarenhas
patent: 2003/0059430 (2003-03-01), Mascarenhas
patent: 2003/0161829 (2003-08-01), Mascarenhas
patent: 2003/0224990 (2003-12-01), Mascarenhas
patent: 2008/0039393 (2008-02-01), Mascarenhas
patent: 2008/0124346 (2008-05-01), Mascarenhas
patent: 2009/0053203 (2009-02-01), Mascarenhas
Alvarez Garcia, B. et al. (Nov. 2003). “High-Sensitivity C-Reactive Protein in High-Grade Carotid Stenosis: Risk Marker for Unstable Carotid Plaque,”Journal of Vascular Sungery38(5):1018-1024.
Ambrosini, G. et al. (Aug. 1997). “A Novel Anti-Apoptosis Gene, Survivin, Expressed in Cancer and Lymphoma,”Nature Medicine3(8):917-921.
Anderson, R. L. et al. (1981). “Temperature-Induced Homeoviscous Adaptation of Chinese Hamster Ovary Cells,”Biochimica et BiophysicaActa 641:334-348.
Antman, K. H. et al. (Nov. 10, 1999). “High-Dose Chemotherapy for Breast Cancer,”JAMA282(18):1701-1703.
Arany, E. et al. (1996). “Rapid Clearance of Human Insulin-Like Growth Factor Binding Protein-3 From the Rat Circulation and Cellular Localization in Liver, Kidney and Stomach,”Growth Regulation6:32-41.
Barnes, J. A. et al. (2001). “Expression of Inducible Hsp70 Enhances the Proliferation of MCF-7 Breast Cancer Cells and Protects Against the Cytotoxic Effects of Hyperthermia,”Cell Stress Chaperones6(4):316-325.
Bosio, A. et al (2002). “Kinetics of Gene Expression Profiling in Swiss 3T3 Cells Exposed to Aqueous Extracts of Cigarette Smoke,”Carinogenesis23(5):741-748.
Butcher, J. (Feb. 2005). “Parkin Gene Therapy Could Treat Parkinson's Disease,”Lancet Neurol. 4:82.
Butt, A. J. et al. (Jul. 2005). “Enhancement of Tumor Necrosis Factor-Alpha-Induced Growth Inhibition by Insulin-Like Growth Factor-Binding Proteins-5 (IGFBP-5), But Not IGFBP-3 in Human Breast Cancer Cells,”Endocrinology146(7):3113-3122.
Campisi, J. et al. (2003). “Stress-Induced Extracellular Hsp72 is a Functionally Significant Danger Signal to the Immune System,”Cell Stress&Chaperones8(3):272-286.
Chong, Y-P. et al. (Sep. 2005). “C-Terminal Src Kinase (CSK) and CSK-Homologous Kinase (CHK)—Endogenous Negative Regulators of Src-Family Protein Kinases,”Growth Factors23(3):233-244.
Ciocca, D. R. et al. (2002). “Hsp27 as a Prognostic and Predictive Factor in Cancer,”in Small Stress Proteins. A.-P. Arrigo et al. eds., Springer-Verlag Berlin Heidelberg, pp. 205-218.
Ciocca, D. R. et al. (Oct. 6, 1993). “Biological and Clinical Implications of Heat Shock Protein 27000 (Hsp27): a Review,”Journal of National Cancer Institute85(19):1558-1570.
Clemmons, D. R. et al. (Jan. 2005). “Interaction Between Insulin-Like Growth Factor-I Receptor and alphaVbeta3 Integrin Linked Signaling Pathways: Cellular Responses to Changes in Multiple Signaling Inputs,”Molecular Endocrinology19(1):1-11.
Cornford, P. A. et al. (Dec. 15, 2000). “Heat Shock Protein Expression Independently Predicts Clinical Outcome in Prostate Cancer,”Cancer Research60:7099-7105.
Darios, F. et al. (2003). “Parkin Prevents Mitochondrial Swelling and Cytochrome C Release in Mitochondria-Dependent Cell Death,”Human Molecular Genetics12(5):517-526.
Dessein, P. H. et al. (2002). “Cardiovascular Risk in Rheumatoid Arthritis Versus Osteoarthritis: Acute Phase Response Related Decreased Insulin Sensitivity and High-Density Lipoprotein Cholesterol as Well as Clustering of Metabolic Syndrome Features in Rheumatoid Arthritis,”Arthritis Research4(5):1-6.
Driscoll, M. et al. (Mar. 2003). “Dying For a Cause: Invertebrate Genetics Takes on Human Neurodegeneration,”Nature Reviews Genetics4:181-194.
Escobar-Morreale, H. F. et al. (Feb. 2004). “Serum Interleukin-18 Concentrations Are Increased in the Polycystic Ovary Syndrome: Relationship to Insulin Resistance and to Obesity,”The Journal of Clinical Endocrinology&Metabolism89(2):806-811.
Firestein, G. S. (May 15, 2003). “Evolving Concepts of Rheumatoid Arthritis,”Nature423:356-361.
Gargalovic, P. et al. (2003). “Cellular Apoptosis is Associated With Increased Caveolin-1 Expression in Macrophages,”Journal of Lipid Research44:1622-1632.
Gobert, A. P. et al. (Jan. 2, 2004). “Helicobacter Pylori Heat Shock Protein 60 Mediates Interleukin-6 Production by Macrophages via a Toll-Like Receptor (TLR)-2-,TLR-4-, and Myeloid Differentiation Factor 88-Independent Mechanism,”The Journal of Biological Chemistry279(1):245-250.
Goldberg, M. S. et al. (Oct. 31, 2003). “Parkin-Deficient Mice Exhibit Nigrostriatal Deficits but Not Loss of Dopaminergic Neurons,”The Journal of Biological Chemistry278(44):43628-43635.
Harkins, M. S. et al. (Dec. 2003). “Regulation of CD23 in the Chronic Inflammatory Response in Asthma: A Role For Interferon-y and Heat-Shock Protein 70 in the TH2 Environment,”Annals of Allergy Asthma&Immunology91:567-574.
Haywood, a. F. M. et al. (2004). “Parkin Counteracts Symptoms in a Drosophila Model of Parkinson's Disease,”BMC Neuroscience. 5:1-12.
Hortobagyi, G. N. (Oct. 1, 1998). “Drug Therapy,”The New England Journal of Medicine339(14):974-984.
Jiang, H. et al. (2004). “Parkin Protects Human Dopaminergic Neuroblastoma Cells Against Dopamine-Induced Apoptosis,”Human Molecular Genetics13(16):1745-1754.
Kaarniranta, K. et al. (2002). “Neuronal Cells Show Regulatory Differences in the hsp70 Gene Response,”Molecular Brain Research101:136-140.
Kiss, A. L. et al. (2002). “Caveolae and Caveolin Isoforms in Rat Peritoneal Macrophages,”Micron33:75-93.
Lee, J-W. et al. (Feb. 2004). “Hypoxia-Inducible Factor (HIF-1) Alpha: Its Protein Stability and Biological Functions,”Experimental and Molecular Medicine36(1):1-12.
Li, F. et al. (Dec. 1999). “Pleiotropic Cell-Division Defects and Apoptosis Induced by Interference With Survivin Function,”Nat Cell Biol. 1(8):461-466.
Lin, E. Y. et al. (2004). “Macrophages: Modulators of Breast Cancer Progression”In Cancer and Inflammation Novartis Foundation Symposium256. John Wiley & Sons, Ltd. pp. 158-172.
Lipton, A. (2005). Business Briefing: North American Pharmacotherapy:109-112.
Lo Bianco, C. et al. (Dec. 14, 2004). “Lentiviral Vector Delivery of Parkin Prevents Dopaminergic Degeneration in an Alpha-Synuclein Rat Model of Parkinson's Disease,”Proceedings of the National Academy of Sciences of the United States of America. 101(50):17510-17515.
Luscher, B. et al. (1999). “The Basic Region/Helix-Loop-Helix/Leucine Zipper Domain of Myc Proto-Oncoproteins: Function and Regulation,”Oncogene18:2955-2966.
Ma, J. et al. (Apr. 7, 2004). “A Prospective Study of Plasma C-Peptide and Colorectal Cancer Risk in Men,”Journal of the National Cancer Institute96(7):546-553.
Malin, A. et al. (Feb. 15, 2004). “Evaluation of the Synergistic Effect of Insulin Resistance and Insulin-Like Growth Factors on the Risk of Breast Carcinoma,”Cancer100(4):694-700.
Martin, C. A. et al. (2003). “Aberrant Extracellular and Dendritic Cell (DC) Surface Expression of Heat Shock Protein (hsp)70 in the Rheumatoid Joint: Possible Mechanisms of hsp/DC-Mediated Cross-Priming,”The Journal of

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