Drug – bio-affecting and body treating compositions – Radionuclide or intended radionuclide containing; adjuvant... – In an organic compound
Patent
1995-06-07
1997-01-14
Kight, John
Drug, bio-affecting and body treating compositions
Radionuclide or intended radionuclide containing; adjuvant...
In an organic compound
424 91, 424 93, 424 94, 534 10, 534 14, 534 15, 530300, 530324, 530325, 530326, 530327, 530328, 530329, 530330, A61K 5100, A61M 3614
Patent
active
055936563
ABSTRACT:
This invention relates to the preparation and use of novel open-chain or cyclic polypeptide constructs in which two or more polypeptide chains, in an open-chain construct, or one or more chains, in a cyclic construct, are chemically derivatized such that the resulting construct exhibits both metal-binding capability and tissue-, organ- or cell-targeting selectivity. In particular, the polypeptide constructs of the present invention comprise compounds of the formula (I): ##STR1## in which, "B" is a hydrocarbon backbone, "P" is a polypeptide capable of targeting particular cells, tissues or organs of the body, "A" may be the group --NR'--NR"-- or the group --NR'--NR"--L-- in which L may be an aliphatic or aromatic linker group, R, R', and R" may be the same or different and may be hydrogen or an aliphatic group, m is an integer.gtoreq.2, provided that the groups R, R', R", L and "P" of a given chain may be the same or different from the groups R, R', R", L and "P" of another chain, n is an integer.gtoreq.0; or a pharmaceutically acceptable salt thereof. The constructs of the present invention are capable of binding a variety of metallic species.
REFERENCES:
patent: 4048326 (1977-09-01), Berg et al.
patent: 4287362 (1981-09-01), Yokoyama et al.
patent: 4305872 (1981-12-01), Johnston et al.
patent: 4548904 (1985-10-01), Kent et al.
patent: 4559221 (1985-12-01), Arano et al.
patent: 4666697 (1987-05-01), Takahashi et al.
patent: 4732864 (1988-03-01), Tolman et al.
patent: 5080884 (1992-01-01), McBride et al.
patent: 5101041 (1992-03-01), Troutner et al.
patent: 5135737 (1992-08-01), Keana
patent: 5138061 (1992-08-01), Belleau et al.
patent: 5162504 (1992-11-01), Horoszewicz et al.
patent: 5196510 (1993-03-01), Rodwell et al.
patent: 5206370 (1993-04-01), Scwartz et al.
patent: 5225180 (1993-07-01), Dean et al.
patent: 5276140 (1994-01-01), Nitecki et al.
patent: 5326856 (1994-07-01), Coughlin et al.
patent: 5382654 (1995-01-01), Lyle et al.
patent: 5449761 (1995-09-01), Belinka, Jr. et al.
Arano et al., Int. J. Nucl. Med Biol. (1986) 12(6):425-430.
Arano et al., J. Nucl. Med. (1987) 28:1027.
Bakker, W. H., et al., J. Nucl. Med. (1990) 21:1501-1509.
Colcher et al., Proc. Natl. Acad. Sci. U.S.A. (1981) 78:3199-3203.
Cullen et al., J. Med. Chem., vol. 35(2), Jan. 24, 1992, pp. 350-361.
D'Angeli et al., J. Org. Chem. (1963) 28:1596-1600.
Dswanjee, Seminar in Nuclear Medicine (1990) 20:5-27.
Granowska et al., Int. J. Colorect. Dis. (1989) 4:97-108.
Hull, Synthetic Commun. (1979) 9:477-481.
Klopping and van der Kerk, Rec. Trav. Chim. (1951) 70:949-961.
Kopunec et al., Radiochem, Radioanal. Lett. (1977) 29:171.
Krenning, E. P., et al., Lancet (1989) 242-245.
Lamb and Kramer, "Commercial Production of Radioisotopes for Nuclear Medicine, " In Radiotracers For Medical Applications, vol. 1, Rayudu (Ed.), CRC Press, Inc., Boca Raton, pp. 17-62.
Lamberts, S. W. J., et al., N. Eng. J. Med. (1990) 323:1246-1249.
Lieber and Slutkin, J. Org. Chem. (1962) 27:2214-2217.
Pinkerton et al., J. Chem. Ed. (1985) 62:965.
Prehn, Richmond T. et al. Cancer Res. (1987) 47:927-932.
Sunkard, Prasad S. et al. Cancer Res. (1987) 47:933-935.
Alvarez Vernon L.
Belinka, Jr. Benjamin A.
Coughlin Daniel J.
Wood Richard
Cytogen Corporation
Jones D. L.
Kight John
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