Organic compounds -- part of the class 532-570 series – Organic compounds – Radioactive metal containing
Patent
1993-09-28
1995-09-12
Geist, Gary L.
Organic compounds -- part of the class 532-570 series
Organic compounds
Radioactive metal containing
534 14, 534 15, 530300, 530326, 530327, 530328, 530399, 530408, 564 18, 564 23, 564 26, 564 27, 564 28, C07C33706, C07C33516, A61K 3800
Patent
active
054497612
ABSTRACT:
This invention relates to the preparation and use of novel open-chain or cyclic polypeptide constructs in which two or more polypeptide chains, in an open-chain construct, or one or more chains, in a cyclic construct, are chemically derivatized such that the resulting construct exhibits both metal-binding capability and tissue-, organ- or cell-targeting selectivity. In particular, the polypeptide constructs of the present invention comprise compounds of the formula (I): ##STR1## in which, "B" is a hydrocarbon backbone, "P" is a polypeptide capable of targeting particular cells, tissues or organs of the body, "A" may be the group --NR'--NR"-- or the group --NR'--NR"--L-- in which L may be an aliphatic or aromatic linker group, R, R' and R" may be the same or different and may be hydrogen or an aliphatic group, m is an integer .gtoreq.2, provided that the groups R, R', R', L and "P" of a given chain may be the same or different from the groups R, R', R", L and "P" of another chain, n is an integer .gtoreq.0; or a pharmaceutically acceptable salt thereof. The constructs of the present invention are capable of binding a variety of metallic species.
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Alvarez Vernon L.
Belinka, Jr. Benjamin A.
Coughlin Daniel J.
Wood Richard
Chapman Lara E.
Cytogen Corporation
Geist Gary L.
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