Metabotropic glutamate receptor agonists in the treatment of cer

Details Metabotropic glutamate receptor agonists in the treatment of cer Metabotropic glutamate receptor agonists in the treatment of cer

1993-12-20

1996-03-19

Criares, Theodore J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Phosphorus containing other than solely as part of an...

514364, 514376, 514747, 514659, 514921, A61K 3166, A61K 3141, A61K 3142, A61K 3113

Patent

active

055004202

ABSTRACT:
Administration of metabotropic glutamate receptor agonists protect neuronal cells from death from cerebral ischemia. Examples of agents are L(+)-2-amino-4-phosphonobutyric acid, trans-amino cyclopentane dicarboxylic acid, (1S,3R)-amino cyclopentane dicarboxylic acid and quisqualic acid.

REFERENCES:
patent: 5081123 (1992-01-01), Honore et al.
patent: 5266594 (1993-11-01), Dawson et al.
Garthwaite, J., et al, Eur. J. Pharmacol. 172, 413-416 (1989).
Koh, J-y, et al, Proc. Natl. Acad. Sci. USA 88, 9431-9835 (Nov. 1991).
Opitz, T., et al, Neuropharmacology, 32(1), 103-104 (1993).
Rothman, S. M., et al, Ann. Neurol. 19, 105-111 (Feb. 1986).
American Heart Association Brochure, 19th International Joint Conference of Stroke and Cerebral Circulation, p. 15, item 63, first mailed Dec. 3, 1993.
Koh, J-y, et al, Brain Res. 561, 338-343 (1991).
Lancaster, J. R., American Scientist 80, 248-257 (May-Jun. 1992).
Sato, S., et al, Biochimica et Biophysica Acta 1181, 195-197 (1993).
Schoepp, D. D., et al, J. Neurochem. 58(3), 1184-1186 (1992).
Chiamulera, C., et al, European J. of Pharmacology 216(2), 335-336 (1992).
Choi, D. W., et al, J. Neurosc. 8(1):185-186 (1988).
Maiese, K., et al, J. Neurosci. Res. 36, 77-87 (1993).
Maiese, K., et al, J. Neurosci. 13, 3034-3040 (1993).
Schoepp, D. D., et al, Trends in Pharmacological Science 14, 13-20 (1993).
Schulte, M. K., et al, Brain Res. 582(2), 291-298 (1992).
Dawson, V. L, et al, Proc. Natl. Acad. Sci. USA, 88, 6368-6371 (Jul. 1991).
Endoh, M., et al, Neurosci. Lett. 154, 125-128 (1993).
Marin, P., et al, Neuropharmacology 32, No. 1, pp. 29-36 (1993).
Mattson, M. P., et al, J. Neurosci. 8, 2087-2100 (Jul. 1988).
Siliprandi, R., et al, Eur. J. Pharmacol. 219(1), 173-174 (1992).
Thomsen, C. P., et al, Eur. J. Pharmacol. 227(3), 361-362 (1992).
Favaron, M., et al, Proc. Natl. Acad. Sci. USA 85, 7351-7355 (Oct. 1988).
Garthwaite, G., et al, Neurosci. 18, No. 2, 437-447 (1986).
Nellgard, B., et al, J. Cereb. Blood Flow Metal 12, 2-11 (1992).
Nowicki, J. P., et al, Euro. J. Pharm. 204, 339-340 (1991).
Trombley, P. Q., J. Neurosci. 12(6), 2043-2050 (Jun. 1992).

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