Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Reexamination Certificate
2006-10-10
2006-10-10
Andres, Janet L. (Department: 1649)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
C435S006120, C435S007210, C435S069100, C435S252300, C435S325000, C436S501000, C530S300000, C530S350000, C514S002600
Reexamination Certificate
active
07119189
ABSTRACT:
The present invention provides purified GABABreceptors and receptor proteins derived from rat and human sources, as well as nucleic acids which encode such proteins. The proteins and nucleic acids of the invention share significant homology with the GABABreceptor and the DNA encoding it as specifically disclosed herein. The invention moreover provides methods for isolating other members of the GABABreceptor family using DNA cloning technology and probes derived from the sequences provided herein, as well as novel members of the GABABreceptor family isolated by such methods.Furthermore, the invention relates to the use of GABABreceptors and receptor proteins and cells transformed with a gene encoding a GABABreceptor protein in a method for identifying and characterising compounds which modulate the activity of the GABABreceptor, such as GABABreceptor agonists and antagonists, which may be useful as pharmacological agents for the treatment of disorders associated with the central and peripheral nervous systems.
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Bettler Bernhard
Bittiger Helmut
Fröstl Wolfgang
Kaupmann Klemens
Mickel Stuart J
Andres Janet L.
Brannock Michael
Novartis AG
Waibel Peter J.
Wilusz, Jr. Edward J.
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