Metabolizable oil emulsion adjuvants and vaccines for...

Drug – bio-affecting and body treating compositions – Nonspecific immunoeffector – per se ; or nonspecific...

Reexamination Certificate

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C424S070190, C424S070310, C424S400000, C424S502000

Reexamination Certificate

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07914801

ABSTRACT:
Water-in-oil priming emulsion vaccines increase the titers and/or avidity indexes of antibodies following a second dose of a commercial or experimental vaccine resulting in increased protection for disease in animal.

REFERENCES:
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patent: 5736125 (1998-04-01), Morawsky et al.
patent: 5744137 (1998-04-01), Stone
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patent: 6720001 (2004-04-01), Chen et al.
patent: WO 98/44948 (1998-10-01), None
patent: WO 9844948 (1998-10-01), None
See Boslego et al (Vaccines and Immunotherapy, 1991, Chapter 17).
Stone, H., et al., “Influence of Formulation on the Efficacy of Experimental Oil-Emulsion Newcastle Disease Vaccines”,Avian Diseases, vol. 27(3), pp. 688-697, 1983.
Stone, H., et al., “Preparation of Inactivated Oil-Emulsion Vaccines with Avian Viral or Mycoplasma Antigens”,Avian Diseases, vol. 22(4), pp. 666-674, 1978.
Stone, H., “Newcastle Disease Oil Emulsion Vaccines Prepared with Animal, Vegetable, and Synthetic Oils”,Avian Diseases, vol. 41, pp. 591-597, 1997.
Stone, H., “Efficacy of Experimental Animal and Vegetable Oil-Emulsion Vaccines for Newcastle Disease and Avian Influenza”,Avian Diseases, vol. 37, pp. 399-405, 1993.

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