Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2007-09-18
2007-09-18
Desai, Rita (Department: 1625)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C546S093000
Reexamination Certificate
active
10874556
ABSTRACT:
The present invention relates to metabolites of tricyclic amides, and structurally related compounds, represented by the structural formula (I):and pharmaceutically acceptable isomers, salts, solvates or esters of the compound of formula (I),wherein:R1is selected from the group consisting of H and ═O;R2-R5can be the same or different, each being independently selected from the group consisting of H, —OH, halide, —NH2and ═O; and,the combination solid-dashed lines independently represent either single bonds or double bonds, wherein the number of combination solid-dashed lines that are double bonds is not greater than 2, and when, the double bonds are not adjacent, and when 0, one of R1-R5is not H.Also disclosed are methods of treatment of proliferative diseases and methods for inhibiting the abnormal growth of cells, and for inhibiting farnesyl protein transferase using the novel compounds.
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Alton Kevin B.
Chan Tze-Ming
Chowdhury Swapan K.
Doll Ronald J.
Feng Wenqing
Desai Rita
Reinhardt Gerard E.
Schering Corporation
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