Metabolically stable puromycin analogs

Details Metabolically stable puromycin analogs Metabolically stable puromycin analogs

2011-03-01

2011-03-01

Lewis, Patrick T (Department: 1623)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C536S027100, C536S027140, C536S027700, C536S027210, C536S027220, C536S027230, C536S027300

Reexamination Certificate

active

07897759

ABSTRACT:
Disclosed are structurally modified, metabolically stable nucleosides having antitumor activity wherein the formation of toxic metabolites is blocked and antimicrobial activity. The disclosure further relates to pharmaceutical compositions comprising one or more disclosed modified nucleosides and to methods of use thereof.

REFERENCES:
Starck et al. JACS (2003), vol. 125, pp. 8090-8091.

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