Chemistry: molecular biology and microbiology – Process of mutation – cell fusion – or genetic modification – Introduction of a polynucleotide molecule into or...
Reexamination Certificate
2006-10-24
2006-10-24
Mosher, Mary E. (Department: 1648)
Chemistry: molecular biology and microbiology
Process of mutation, cell fusion, or genetic modification
Introduction of a polynucleotide molecule into or...
C424S093100, C424S199100, C424S093300, C424S093600, C435S069100, C435S091100, C435S325000, C435S455000, C435S456000, C435S457000, C536S023100, C536S023720, C536S024300, C514S04400A
Reexamination Certificate
active
07125717
ABSTRACT:
Recombinant viral vectors, especially parvovirus vectors such as adeno-associated virus (AAV) vectors, capable of enhanced expression of heterologous sequences, and methods for their construction and use, are provided. The vectors have a structure, or are capable of rapidly adopting a structure, which involves intrastrand base pairing of at least one region in a heterologous sequence.
REFERENCES:
patent: 5173414 (1992-12-01), Lebkowski et al.
patent: 5399346 (1995-03-01), Anderson et al.
patent: 5478745 (1995-12-01), Samulski et al.
patent: 5587308 (1996-12-01), Carter et al.
patent: 5605690 (1997-02-01), Jacobs et al.
patent: 5658776 (1997-08-01), Flotte et al.
patent: 5658785 (1997-08-01), Johnson
patent: 5677158 (1997-10-01), Zhou et al.
patent: 5753500 (1998-05-01), Shenk et al.
patent: 5756283 (1998-05-01), Wilson et al.
patent: 5786211 (1998-07-01), Johnson
patent: 5837484 (1998-11-01), Trempe et al.
patent: 5858775 (1999-01-01), Johnson
patent: 5866696 (1999-02-01), Carter et al.
patent: 5869305 (1999-02-01), Samulski et al.
patent: 5989540 (1999-11-01), Carter et al.
patent: 5990279 (1999-11-01), Carter et al.
patent: 6165781 (2000-12-01), Carter et al.
patent: 6596535 (2003-07-01), Carter
patent: WO 95/13365 (1995-05-01), None
patent: WO 95/13392 (1995-05-01), None
patent: WO 96/17947 (1996-06-01), None
patent: WO 96/39530 (1996-12-01), None
patent: WO 97/17458 (1997-05-01), None
patent: WO 97/32990 (1997-09-01), None
patent: WO 98/27204 (1998-06-01), None
patent: WO 98/27207 (1998-06-01), None
patent: WO-98/32880 (1998-07-01), None
patent: WO 99/11764 (1999-03-01), None
patent: WO 99/20773 (1999-04-01), None
patent: WO 99/20779 (1999-04-01), None
patent: WO 00/14205 (2000-03-01), None
patent: WO 00/65038 (2000-11-01), None
patent: WO 00/73481 (2000-12-01), None
patent: WO-01/11034 (2001-02-01), None
patent: WO-01/11034 (2001-02-01), None
Atkinson E. M. et al. (1998). “A High-Throughput Hybridization Method For Titer Determination Of Viruses and Gene Therapy Vectors,”Nucleic Acids Res. 26(11):2821-2823.
Balagué, C. et al. (Apr. 1997). “Adeno-Associated Virus Rep78 Protein and Terminal Repeats Enhance Integration of DNA Sequences Into the Cellular Genome,”J. Virol. 71(4):3299-3306.
Bantel-Schaal, U. et al. (1988). “Adeno-Associated Viruses Inhibit Sv40 DNA Amplification and Replication Of Herpes Simplex Virus In Sv40-Transformed Hamster Cells,”Virology164:64-74.
Bantel-Schaal, U. et al. (1988). “Dissociation Of Carcinogen-Induced Sv40 DNA-Amplification and Amplification Of AAV DNA In A Chinese Hamster Cell Line,”Virology166:113-122.
Berns (1995). “Parvoviridae and Their Replication,” Chapter 62In Virology, vol. 2, Raven Press, New York pp. 1743-1763.
Berns, K. I. (1995). “Hepatitis B Virus,” Chapter 77In Virology, vol. 2, Raven Press, New York pp. 2173-2197.
Carter, B. J. (1983). “Variant and Defective Interfering Parvoviruses,” Chapter 6In The Parvoviruses. K. I. Berns, ed., Plenum Press, New York, pp. 209-258.
Carter, B. J. (1989). “Adeno-Associated Virus Helper Functions,” in Chapter 13In Handbook of Parvovirusesvol. I, pp. 169-228.
Carter, B. J. (1992). “Adeno-Associated Virus Vectors,”Curr. Op. Biotechnol. 3:533-539.
Clark, K. R.et al. (1995). “Cell Lines For The Production Of Recombinant Adeno-Associated Virus,”Hum. Gene Therapy6:1329-1341.
Cromartie, W. J. et al. (1977). “Arthritis In Rats After Systemic Injection Of Streptococcal Cells Or Cell Walls,”J. Exp. Med. 146:1585-1602.
De la Maza, L. M. and Carter, B. J. (1980). “Molecular Structure Of Adeno-Associated Virus Variant DNA,”J. Biol. Chem. 255:3194-3203.
Dong, J. Y. et al. (1996). “Quantitative Analysis Of The Packaging Capacity Of Recombinant Adeno-Associated Virus,”Hum. Gene Therapy7:2101-2112.
Ferrari, F. K. et al. (1996). “Second-Strand Synthesis Is A Rate-Limiting Step For Efficient Transduction By Recombinant Adeno-Associated Virus Vectors,”J. Virol. 70:3227-3234.
Ferrari, F.K. et al. (Nov. 1997). “New Developments in the Generation of Ad-Free, High-Titer rAAV Gene Therapy Vectors,”Nature Med. 3(11):1295-1297.
Fisher, K. J. et al. (1996). “Transduction With Recombinant Adeno-Associated Virus For Gene Therapy Is Limited By Leading-Strand Synthesis,”J. Virol. 70:520-532.
Flotte, T. R. and Carter, B. J. (1995). “Adeno-Associated Virus Vectors For Gene Therapy,”Gene Therapy2:357-362.
Flotte, T. R. et al. (1992). “Gene Expression From Adeno-Associated Virus Vectors In Airway Epithelial Cells,”Am. J. Respir. Cell. Mol. Biol. 7:349-356.
Flotte, T.R. et al. (Feb. 15, 1993). “Expresssion of the Cystic Fibrosis Transmembrane Conductance Regulator from a Novel Adeno-Associated Virus Promoter,”J. Biol. Chem. 268(5):3781-3790.
Hauswirth, W. W. and Berns, K. I. (1979). “Adeno-Associated Virus DNA Replication: Nonunit-Length Molecules,”Virology93:57-68.
Hermonat, P. L. and Muzyczka, N. (1984). “Use Of Adeno-Associated Virus As A Mammalian DNA Cloning Vector: Transduction Of Neomycin Resistance Into Mammalian Tissue Culture Cells,”Proc. Natl. Acad. Sci. USA, 81:6466.
Hermonat, P. L. et al. (1984). “Genetics Of Adeno-Associated Virus: Isolation and Preliminary Characterization Of Adeno-Associated Virus Type 2 Mutants,”J. Virol. 51:329-339.
Lebkowski, J. S. et al. (1988). “Adeno-Associated Virus: A Vector System For Efficient Introduction and Integration Of DNA Into A Variety Of Mammalian Cell Types,”Mol. Cell. Biol.8(10):3988-3996.
Lynch, C. M. et al. (1997). “Adeno-Associated Virus Vectors For Vascular Gene Delivery,”Circ. Res. 80:497-505.
McLaughlin, S. K. et al. (1988). “Adeno-Associated Virus General Transduction Vectors: Analysis Of Provirual Structures,”J. Virol. 62:1963.
Muzyczka, N. (1992). “Use Of Adeno-Associated Virus As A General Transduction Vector For Mammalian Cells,”Curr. Top. Microbiol. Immunol. 158:97-129.
Russell, J. et al. (1995). “Cis-Acting Components Of Human Papillomavirus (Hpv) Dna Replication: Linker Substitution Analysis Of The Hpv Type 11 Origin,”J. Virol. 69(2):651-660.
Samulski, R. J. et al. (1989). “Helper-Free Stocks Of Recombinant Adeno-Associated Viruses: Normal Integration Does Not Require Viral Gene Expression,”J. Virol. 63:3822-3828.
Sanlioglu, S. Et al. (Mar. 1, 1999). “Two Independent Pathways for Recombinant Adeno-Associated Virus Genome Conversion Occur After UV-C and E4orf6 Augmentation of Transduction,”Hum. Gene Ther. 10:591-602.
Srivastava, A. et al. (1983). “Nucleotide Sequence and Organization Of The Adeno-Associated Virus 2 Genome,”J. Virol. 45:555-564.
Tratschin, J. et al. (1984). “A Human Parvovirus, Adeno-Associated Virus, As A Eucaryotic Vector: Transient Expression and Encasidation Of The Procaryotic Gene For Chloramphenicol Acetyltransferase,”Mol. Cell. Biol. 4:2072-2081.
Tratschin, J. et al. (1984). “Genetic Analysis Of Adeno-Associated Virus: Properties Of Deletion Mutants Constructed In Vitro and Evidence For An Adeno-Associated Virus Replication Function,”J. Virol. 51:611-619.
Tratschin, J. et al. (1985). “Adeno-Associated Virus Vector For High-Frequency Integration, Expresion and Rescue Of Genes In Mammalian Cells,”Mol. Cell. Biol. 5(11):3251-3260.
Urcelay, E. et al. (Apr. 1995). “Asymmetric Replication In Vitro from a Human Sequence Element is Dependent on Adeno-Associated Virus Rep Protein,”J. Virol. 69(4):2038-2046.
Yakobson, B. et al. (1987). “Replication Of Adeno-Associated Virus In Synchronized Cells Without The Addition Of A Helper Virus,”J. Virol. 61:972-987.
Yakobson, B. et al. (1988). “Replication Of Adeno-Associated Virus In Cells Irradiated With Uv Light At 254nm,”J. Virol. 63:1023-1030.
Yalkinoglu, A. O. et al. (1988). “DNA Amplification Of
Mosher Mary E.
Peng Bo
Targeted Genetics Corporation
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