Metabolic pathway engineering to increase production of ascorbic

Details Metabolic pathway engineering to increase production of ascorbic Metabolic pathway engineering to increase production of ascorbic

1988-08-08

1991-07-16

Robinson, Douglas W.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing oxygen-containing organic compound

4351723, C12P 760, C12N 1503

Patent

active

050325140

ABSTRACT:
In recombinant microorganisms which were rendered capable of converting 2,5-diketo-D-gluconic acid (2,5-DKG) to 2-keto-L-gulonic acid (2-KLG) by transfer of genetic material, the secondary metabolites and metabolic pathways leading to the metabolic diversion of 2-KLG and 2,5-DKG were determined, and the diversion of 2-KLG to L-iodonic acid (IA) or of 2,5-DKG to 5-keto-D-gluconate (5-KDH) was blocked.

REFERENCES:
patent: 2917435 (1959-12-01), Perlman
patent: 4748122 (1988-05-01), Sonoyama et al.
patent: 4757012 (1988-07-01), Estell et al.
Anderson et al., "Production of 2-keto-l-gulonate, An Intermediate in l-Ascorbate Synthesis", by a Genetically Modified Erlvinia herbicola, Science, 230:144-149, 1985.

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